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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	6,995,858	6,995,858
TRV GP V LLC	[2025-06-30]	SOLE	6,215,591	6,215,591
Driehaus Capital Management LLC	[2025-06-30]	SOLE	4,020,525	4,680,431
BVF Inc/IL	[2025-06-30]	DFND	0	4,396,124
TRV GP VI LLC	[2025-06-30]	SOLE	4,211,659	4,211,659
Samsara Biocapital LLC	[2025-06-30]	SOLE	3,149,128	3,149,128
Siren, L.L.C.	[2025-06-30]	DFND	2,202,514	2,202,514
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,416,314	1,416,314
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,398,393
BlackRock, Inc.	[2025-06-30]	SOLE	1,349,290	1,390,800
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	1,237,500	1,237,500
Adar1 Capital Management LLC	[2025-06-30]	SOLE	847,227	847,227
Susquehanna International Group LLP	[2025-06-30]	OTR	166,506	722,206
Checkpoint Capital LP	[2025-06-30]	SOLE	586,473	586,473
SIO Capital Management LLC	[2025-06-30]	SOLE	584,435	584,435
Casdin Capital LLC	[2025-06-30]	SOLE	553,268	553,268
Perceptive Advisors LLC	[2025-06-30]	SOLE	541,450	541,450
VR Adviser LLC	[2025-06-30]	SOLE	540,453	540,453
Geode Capital Management LLC	[2025-06-30]	DFND	487,956	487,956
Jane Street Group LLC	[2025-06-30]	DFND	448,300	448,300
State Street Corp	[2025-06-30]	DFND	345,292	369,992
Catalio Capital Management LP	[2025-06-30]	SOLE	294,360	294,360
Woodline Partners LP	[2025-06-30]	SOLE	282,585	282,585
Universal- Beteiligungs- und Servicegesellschaft mbH	[2025-06-30]	DFND	222,702	222,702
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	154,781	154,781
Northern Trust Corp	[2025-06-30]	DFND	150,983	150,983
Citadel Advisors LLC	[2025-06-30]	DFND	130,274	130,274
Deep Track Capital LP	[2025-06-30]	SOLE	121,716	121,716
Logos Global Management LP	[2025-06-30]	SOLE	109,202	109,202
Bank of America Corp /DE/	[2025-06-30]	DFND	4,142	99,213
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