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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	5,498,170	5,498,170
Whetstone Capital Advisors LLC	[2025-06-30]	SOLE	3,632,371	3,632,371
Aberdeen Group plc	[2025-06-30]	DFND	2,227,367	2,227,367
Vivo Capital LLC	[2025-06-30]	SOLE	1,650,440	1,650,440
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,152,013
AWM Investment Company Inc	[2025-06-30]	SOLE	680,931	680,931
Citadel Advisors LLC	[2025-06-30]	DFND	641,307	641,307
Captrust Financial Advisors	[2025-06-30]	SOLE	67,053	602,277
Geode Capital Management LLC	[2025-06-30]	DFND	302,410	302,410
Sanders Morris Harris LLC	[2025-06-30]	SOLE	263,600	263,600
Millennium Management LLC	[2025-06-30]	SOLE	184,564	184,564
BlackRock, Inc.	[2025-06-30]	SOLE	145,279	145,279
Perkins Capital Management Inc	[2025-06-30]	SOLE	128,500	131,000
State Street Corp	[2025-06-30]	DFND	121,592	121,592
Corient Private Wealth LLC	[2025-06-30]	SOLE	0	100,000
Wealth Enhancement Advisory Services LLC	[2025-06-30]	SOLE	95,973	99,155
Northern Trust Corp	[2025-06-30]	DFND	91,635	91,635
Morgan Stanley	[2025-06-30]	DFND	11,479	91,382
Squarepoint Ops LLC	[2025-06-30]	DFND	0	85,420
CliftonLarsonAllen Wealth Advisors LLC	[2025-06-30]	SOLE	0	78,855
Bank of New York Mellon Corp	[2025-06-30]	DFND	76,757	76,757
Perigon Wealth Management LLC	[2025-06-30]	SOLE	0	72,685
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	67,692	67,692
GSA Capital Partners LLP	[2025-06-30]	SOLE	62,534	62,534
Requisite Capital Management LLC	[2025-06-30]	SOLE	0	55,648
Ballentine Partners LLC	[2025-06-30]	SOLE	0	49,664
Goldman Sachs Group Inc	[2025-06-30]	DFND	45,914	45,914
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	45,705	45,705
Twelve Points Wealth Management LLC	[2025-06-30]	SOLE	0	43,388
Hightower Advisors LLC	[2025-06-30]	SOLE	42,984	42,984
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