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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
5AM Venture Management LLC	[2025-06-30]	SOLE	9,913,168	9,913,168
Versant Venture Management LLC	[2025-06-30]	OTR	0	2,007,704
Baker Bros Advisors LP	[2025-06-30]	SOLE	1,450,638	1,450,638
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	1,097,864	1,097,864
Vanguard Group Inc	[2025-06-30]	SOLE	0	833,404
Ensign Peak Advisors, Inc	[2025-06-30]	SOLE	767,287	767,287
Driehaus Capital Management LLC	[2025-06-30]	SOLE	620,395	620,395
Sphera Funds Management Ltd	[2025-06-30]	DFND	538,434	538,434
Millennium Management LLC	[2025-06-30]	SOLE	470,729	470,729
Alyeska Investment Group LP	[2025-06-30]	SOLE	456,163	456,163
BlackRock, Inc.	[2025-06-30]	SOLE	409,433	412,617
Platinum Investment Management Ltd	[2025-06-30]	SOLE	293,320	293,320
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	[2025-06-30]	DFND	289,979	289,979
Geode Capital Management LLC	[2025-06-30]	DFND	201,921	201,921
Fred Alger Management LLC	[2025-06-30]	SOLE	201,451	201,451
Susquehanna International Group LLP	[2025-06-30]	OTR	73,719	136,519
Marshall Wace LLP	[2025-06-30]	OTR	0	104,347
LPL Financial LLC	[2025-06-30]	SOLE	0	77,102
Goldman Sachs Group Inc	[2025-06-30]	DFND	73,833	73,834
State Street Corp	[2025-06-30]	DFND	66,700	66,700
Two Sigma Investments LP	[2025-06-30]	SOLE	63,155	63,155
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	52,204	52,204
Capital Advisors Wealth Management LLC	[2025-06-30]	SOLE	50,800	50,800
Citadel Advisors LLC	[2025-06-30]	DFND	50,100	50,100
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	42,000	42,000
UBS Group AG	[2025-06-30]	DFND	41,523	41,523
Zurcher Kantonalbank (Zurich Cantonalbank)	[2025-06-30]	SOLE	31,847	31,847
Northern Trust Corp	[2025-06-30]	DFND	29,004	29,004
AQR Capital Management LLC	[2025-06-30]	DFND	28,445	28,445
HRT Financial LP	[2025-06-30]	DFND	20,036	20,036
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