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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
TCG Crossover Management LLC	[2025-06-30]	SOLE	3,033,560	3,033,560
Siren, L.L.C.	[2025-06-30]	DFND	2,911,438	2,911,438
Redmile Group LLC	[2025-06-30]	SOLE	2,164,777	2,164,777
Lombard Odier Asset Management USA Corp	[2025-06-30]	OTR	1,849,734	1,849,734
Morgan Stanley	[2025-06-30]	DFND	1,129,430	1,211,758
Vivo Capital LLC	[2025-06-30]	SOLE	1,105,454	1,105,454
Nantahala Capital Management LLC	[2025-06-30]	SOLE	1,042,427	1,042,427
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	970,130	970,130
Nextech Invest Ltd	[2025-06-30]	SOLE	952,400	952,400
Ikarian Capital LLC	[2025-06-30]	SOLE	873,568	873,568
Cantor Fitzgerald L P	[2025-06-30]	DFND	0	789,039
5AM Venture Management LLC	[2025-06-30]	SOLE	476,200	476,200
SG Americas Securities LLC	[2025-06-30]	SOLE	308,331	308,331
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	252,421
UBS Group AG	[2025-06-30]	DFND	227,309	228,509
Millennium Management LLC	[2025-06-30]	SOLE	198,647	198,647
M28 Capital Management LP	[2025-06-30]	SOLE	185,100	185,100
Marshall Wace LLP	[2025-06-30]	OTR	0	175,862
HSBC Holdings PLC	[2025-06-30]	DFND	172,834	172,834
BlackRock, Inc.	[2025-06-30]	SOLE	168,235	168,235
Bank of Montreal /Can/	[2025-06-30]	DFND	140,812	145,812
Woodline Partners LP	[2025-06-30]	SOLE	62,459	62,459
Jane Street Group LLC	[2025-06-30]	DFND	37,813	60,613
Two Sigma Investments LP	[2025-06-30]	SOLE	59,312	59,312
Osaic Holdings Inc	[2025-06-30]	DFND	0	40,867
Two Sigma Advisers LP	[2025-06-30]	SOLE	35,100	39,600
Saturn V Capital Management LP	[2025-06-30]	SOLE	34,737	34,737
Geode Capital Management LLC	[2025-06-30]	DFND	29,538	29,538
Susquehanna International Group LLP	[2025-06-30]	OTR	27,797	27,797
Wexford Capital LP	[2025-06-30]	SOLE	27,149	27,149
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