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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Blackstone Inc.	[2022-03-31]	OTR	0.0	25,156,993.0
Deerfield Management Company LP Series C	[2022-03-31]	DFND	13,848,488.0	13,848,488.0
SB Management Ltd	[2022-03-31]	DFND	7,450,439.0	7,450,439.0
Vanguard Group Inc	[2022-03-31]	SOLE	0.0	5,406,641.0
Casdin Capital LLC	[2022-03-31]	SOLE	5,000,000.0	5,000,000.0
Marshall Wace LLP	[2022-03-31]	OTR	0.0	4,825,384.0
Corvex Management LP	[2022-03-31]	SOLE	4,500,000.0	4,500,000.0
Third Point LLC	[2022-03-31]	SOLE	4,295,000.0	4,295,000.0
Oracle Investment Management Inc	[2022-03-31]	SOLE	3,944,832.0	3,944,832.0
Decheng Capital Management III (Cayman), LLC	[2022-03-31]	SOLE	3,418,929.0	3,418,929.0
Perceptive Advisors LLC	[2022-03-31]	SOLE	2,500,000.0	2,500,000.0
BlackRock Inc.	[2022-03-31]	SOLE	2,363,183.0	2,456,595.0
Deutsche Bank AG	[2022-03-31]	DFND	0.0	2,191,835.0
Gagnon Securities LLC	[2022-03-31]	SOLE	0.0	1,892,670.0
D. E. Shaw & Co., Inc.	[2022-03-31]	DFND	1,835,013.0	1,835,013.0
Caption Management LLC	[2022-03-31]	SOLE	1,818,811.0	1,818,811.0
Price T Rowe Associates Inc /MD/	[2022-03-31]	SOLE	369,480.0	1,818,291.0
Susquehanna International Group LLP	[2022-03-31]	DFND	1,034,799.0	1,583,299.0
Gagnon Advisors LLC	[2022-03-31]	SOLE	0.0	1,478,200.0
Geode Capital Management LLC	[2022-03-31]	DFND	1,358,348.0	1,358,348.0
Driehaus Capital Management LLC	[2022-03-31]	SOLE	1,156,426.0	1,156,426.0
State Street Corp	[2022-03-31]	DFND	1,063,830.0	1,137,530.0
Weiss Multi-Strategy Advisers LLC	[2022-03-31]	SOLE	0.0	1,132,873.0
JS Capital Management LLC	[2022-03-31]	SOLE	1,000,000.0	1,000,000.0
Avidity Partners Management LP	[2022-03-31]	SOLE	950,000.0	950,000.0
Zweig-Dimenna Associates LLC	[2022-03-31]	SOLE	935,312.0	935,312.0
Islet Management LP	[2022-03-31]	SOLE	849,190.0	849,190.0
Millennium Management LLC	[2022-03-31]	SOLE	671,230.0	671,230.0
Charles Schwab Investment Management Inc	[2022-03-31]	SOLE	626,304.0	626,304.0
Newtyn Management LLC	[2022-03-31]	SOLE	600,000.0	600,000.0
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