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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	7,003,734.0
BlackRock Inc.	[2023-03-31]	SOLE	4,783,283.0	4,900,841.0
State Street Corp	[2023-03-31]	DFND	3,747,413.0	3,866,230.0
Avidity Partners Management LP	[2023-03-31]	SOLE	3,865,300.0	3,865,300.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	3,708,838.0	3,708,838.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,390,885.0
Kynam Capital Management LP	[2023-03-31]	SOLE	3,205,986.0	3,205,986.0
Avoro Capital Advisors LLC	[2023-03-31]	SOLE	2,650,000.0	2,650,000.0
Paradigm Biocapital Advisors LP	[2023-03-31]	SOLE	2,274,512.0	2,274,512.0
Jennison Associates LLC	[2023-03-31]	DFND	2,213,629.0	2,213,629.0
Eversept Partners LP	[2023-03-31]	SOLE	2,209,057.0	2,209,057.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	2,143,197.0
PFM Health Sciences LP	[2023-03-31]	DFND	0.0	1,946,652.0
OrbiMed Advisors LLC	[2023-03-31]	DFND	401,200.0	1,711,675.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,598,669.0	1,598,669.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	1,194,306.0	1,250,174.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,227,601.0	1,227,601.0
Morgan Stanley	[2023-03-31]	DFND	1,059,011.0	1,093,844.0
Sofinnova Investments Inc	[2023-03-31]	SOLE	1,075,424.0	1,075,424.0
Aisling Capital Management LP	[2023-03-31]	SOLE	1,025,000.0	1,025,000.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	391,315.0	1,000,715.0
Barclays PLC	[2023-03-31]	SOLE	981,886.0	981,886.0
Nantahala Capital Management LLC	[2023-03-31]	SOLE	975,705.0	975,705.0
Braidwell LP	[2023-03-31]	SOLE	920,049.0	920,049.0
Foresite Capital Management IV, LLC	[2023-03-31]	SOLE	875,000.0	875,000.0
Commodore Capital LP	[2023-03-31]	SOLE	853,884.0	853,884.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	790,000.0	790,000.0
Sphera Funds Management Ltd	[2023-03-31]	DFND	683,061.0	683,061.0
Citigroup Inc	[2023-03-31]	DFND	620,215.0	620,215.0
Palo Alto Investors LP	[2023-03-31]	SOLE	612,600.0	612,600.0
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