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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RTW Investments LP	[2023-03-31]	SOLE	2,548,125.0	2,548,125.0
Vivo Capital LLC	[2023-03-31]	SOLE	2,262,200.0	2,262,200.0
Tang Capital Management LLC	[2023-03-31]	OTR	0.0	2,034,158.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	1,787,527.0	1,787,527.0
BlackRock Inc.	[2023-03-31]	SOLE	1,429,830.0	1,457,260.0
Cormorant Asset Management LP	[2023-03-31]	DFND	1,421,422.0	1,421,422.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	1,296,416.0	1,296,416.0
TimesSquare Capital Management LLC	[2023-03-31]	SOLE	1,192,660.0	1,192,660.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,192,315.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	1,156,032.0	1,156,032.0
Jefferies Financial Group Inc.	[2023-03-31]	DFND	445,758.0	445,758.0
State Street Corp	[2023-03-31]	DFND	345,695.0	364,295.0
Geode Capital Management LLC	[2023-03-31]	DFND	349,149.0	349,149.0
Sands Capital Ventures LLC	[2023-03-31]	SOLE	260,000.0	260,000.0
Ensign Peak Advisors, Inc	[2023-03-31]	SOLE	242,451.0	242,451.0
Rubric Capital Management LP	[2023-03-31]	SOLE	221,488.0	221,488.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	187,904.0	210,083.0
Northern Trust Corp	[2023-03-31]	DFND	1,068.0	151,366.0
Macquarie Group Ltd	[2023-03-31]	SOLE	150,000.0	150,000.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	146,194.0	146,194.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	139,151.0	139,151.0
UBS OConnor LLC	[2023-03-31]	DFND	98,175.0	98,175.0
Ghost Tree Capital LLC	[2023-03-31]	SOLE	80,000.0	80,000.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	71,200.0	74,000.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	61,178.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	51,012.0	58,713.0
Citadel Advisors LLC	[2023-03-31]	DFND	55,156.0	55,156.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	43,880.0	43,880.0
J Goldman & Co LP	[2023-03-31]	SOLE	41,573.0	41,573.0
Swiss National Bank	[2023-03-31]	SOLE	37,433.0	37,433.0
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