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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Soleus Capital Management LP	[2025-06-30]	SOLE	8,167,100	8,167,100
OrbiMed Advisors LLC	[2025-06-30]	SOLE	7,562,971	7,562,971
Deep Track Capital LP	[2025-06-30]	SOLE	7,495,000	7,495,000
Morgan Stanley	[2025-06-30]	DFND	7,241,018	7,253,469
Vivo Capital LLC	[2025-06-30]	SOLE	6,895,746	6,895,746
BlackRock, Inc.	[2025-06-30]	SOLE	5,340,644	5,470,374
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,254,257
Citadel Advisors LLC	[2025-06-30]	DFND	3,988,511	3,988,511
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	3,049,891	3,049,891
Candriam S.C.A.	[2025-06-30]	SOLE	2,368,235	2,368,235
Acorn Capital Advisors LLC	[2025-06-30]	SOLE	1,971,264	1,971,264
Geode Capital Management LLC	[2025-06-30]	DFND	1,633,349	1,633,349
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,479,507	1,549,334
State Street Corp	[2025-06-30]	DFND	1,295,641	1,373,441
Superstring Capital Management LP	[2025-06-30]	SOLE	1,286,681	1,286,681
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,280,000	1,280,000
Franklin Resources Inc	[2025-06-30]	DFND	1,277,396	1,277,396
Nuveen, LLC	[2025-06-30]	DFND	1,177,520	1,180,528
UBS Group AG	[2025-06-30]	DFND	1,161,494	1,171,619
Millennium Management LLC	[2025-06-30]	SOLE	996,826	996,826
Renaissance Technologies LLC	[2025-06-30]	SOLE	922,534	922,534
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	817,808	817,808
Integral Health Asset Management LLC	[2025-06-30]	SOLE	700,000	700,000
Northern Trust Corp	[2025-06-30]	DFND	559,850	559,850
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	506,777
Bank of America Corp /DE/	[2025-06-30]	DFND	12,807	493,805
Acuta Capital Partners LLC	[2025-06-30]	SOLE	463,864	463,864
Diadema Partners LP	[2025-06-30]	SOLE	420,752	420,752
Walleye Capital LLC	[2025-06-30]	SOLE	376,559	376,559
Schroder Investment Management Group	[2025-06-30]	SOLE	376,204	376,204
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