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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Soleus Capital Management LP	[2025-06-30]	SOLE	4,801,376	4,801,376
Nantahala Capital Management LLC	[2025-06-30]	SOLE	2,422,563	2,422,563
AIGH Capital Management LLC	[2025-06-30]	SOLE	1,549,088	1,549,088
Morgan Stanley	[2025-06-30]	DFND	852,939	858,614
AIGH Capital Management LLC	[2025-06-30]	OTR	0	533,403
National Bank of Canada /FI/	[2025-06-30]	DFND	0	222,870
Stonepine Capital Management LLC	[2025-06-30]	SOLE	189,051	189,051
Osaic Holdings Inc	[2025-06-30]	DFND	0	163,140
Alberta Investment Management Corp	[2025-06-30]	SOLE	150,000	150,000
Skandinaviska Enskilda Banken AB (publ)	[2025-06-30]	SOLE	132,639	132,639
Harbour Investments Inc	[2025-06-30]	SOLE	0	96,038
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	94,611	94,611
Susquehanna International Group LLP	[2025-06-30]	OTR	80,674	80,674
Stifel Financial Corp	[2025-06-30]	DFND	75,134	79,596
PenderFund Capital Management Ltd.	[2025-06-30]	SOLE	69,900	69,900
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	55,459
Wealthspire Advisors LLC	[2025-06-30]	SOLE	0	51,250
Rangeley Capital LLC	[2025-06-30]	SOLE	50,000	50,000
Hamilton Capital LLC	[2025-06-30]	SOLE	0	44,072
Cyndeo Wealth Partners LLC	[2025-06-30]	SOLE	0	29,691
MAI Capital Management	[2025-06-30]	SOLE	0	29,242
Federation des caisses Desjardins du Quebec	[2025-06-30]	DFND	27,978	27,978
Bank of America Corp /DE/	[2025-06-30]	DFND	26,300	27,587
BARE Financial Services Inc	[2025-06-30]	SOLE	26,782	26,782
Beacon Pointe Advisors LLC	[2025-06-30]	SOLE	26,525	26,525
Citadel Advisors LLC	[2025-06-30]	DFND	25,250	25,250
Yakira Capital Management Inc	[2025-06-30]	SOLE	24,000	24,000
Geode Capital Management LLC	[2025-06-30]	DFND	23,971	23,971
Goldman Sachs Group Inc	[2025-06-30]	DFND	22,225	22,225
Bank of Montreal /Can/	[2025-06-30]	DFND	22,099	22,099
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