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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Curative Ventures V LLC	[2025-06-30]	DFND	0	1,899,004
BML Capital Management LLC	[2025-06-30]	SOLE	0	534,899
CPMG Inc	[2025-06-30]	SOLE	410,922	410,922
Vivo Capital LLC	[2025-06-30]	SOLE	292,743	292,743
Siren, L.L.C.	[2025-06-30]	DFND	203,933	203,933
Vanguard Group Inc	[2025-06-30]	SOLE	0	166,628
Goldman Sachs Group Inc	[2025-06-30]	DFND	163,261	163,261
Millennium Management LLC	[2025-06-30]	SOLE	108,097	108,097
Morgan Stanley	[2025-06-30]	DFND	96,258	96,308
Balyasny Asset Management LP	[2025-06-30]	SOLE	88,796	88,796
Sectoral Asset Management Inc	[2025-06-30]	SOLE	15,850	86,220
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	76,895	76,895
Boxer Capital Management LLC	[2025-06-30]	SOLE	0	70,700
Renaissance Technologies LLC	[2025-06-30]	SOLE	70,655	70,655
Northern Trust Corp	[2025-06-30]	DFND	64,413	64,413
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	57,497	57,497
BlackRock, Inc.	[2025-06-30]	SOLE	50,733	50,733
Macquarie Group Ltd	[2025-06-30]	SOLE	50,000	50,000
Geode Capital Management LLC	[2025-06-30]	DFND	43,094	43,094
State Street Corp	[2025-06-30]	DFND	17,595	17,595
Trexquant Investment LP	[2025-06-30]	SOLE	17,369	17,369
UBS Group AG	[2025-06-30]	DFND	16,219	16,219
Exome Asset Management LLC	[2025-06-30]	SOLE	16,200	16,200
Americana Partners LLC	[2025-06-30]	SOLE	0	12,926
Barclays PLC	[2025-06-30]	SOLE	10,400	10,400
Alphaquest LLC	[2025-06-30]	SOLE	7,987	7,987
Dimensional Fund Advisors LP	[2025-06-30]	DFND	0	5,927
GF Fund Management Co Ltd	[2025-06-30]	SOLE	3,000	3,000
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	2,727
Vanguard Group Inc	[2025-06-30]	DFND	0	1,470
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