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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	12,000,000.0	12,000,000.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	3,360,052.0	3,360,052.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,882,931.0
BlackRock Inc.	[2023-03-31]	SOLE	912,974.0	923,917.0
Triatomic Management LP	[2023-03-31]	SOLE	810,145.0	810,145.0
Geode Capital Management LLC	[2023-03-31]	DFND	532,067.0	532,067.0
State Street Corp	[2023-03-31]	DFND	398,069.0	419,621.0
Redmile Group LLC	[2023-03-31]	SOLE	318,082.0	318,082.0
ProSight Management LP	[2023-03-31]	SOLE	281,902.0	281,902.0
Northern Trust Corp	[2023-03-31]	DFND	6,885.0	262,378.0
Saba Capital Management LP	[2023-03-31]	SOLE	174,513.0	174,513.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	3,820.0	132,500.0
Josh Arnold Investment Consultant LLC	[2023-03-31]	SOLE	0.0	116,843.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	88,819.0	93,656.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	87,594.0	87,594.0
Vanguard Group Inc	[2023-03-31]	DFND	0.0	60,612.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	52,343.0	52,343.0
Jane Street Group LLC	[2023-03-31]	DFND	47,127.0	47,127.0
Susquehanna International Group LLP	[2023-03-31]	DFND	44,019.0	44,019.0
Two Sigma Investments LP	[2023-03-31]	SOLE	42,775.0	42,775.0
RhumbLine Advisers	[2023-03-31]	SOLE	15,625.0	38,600.0
Allspring Global Investments Holdings, LLC	[2023-03-31]	DFND	0.0	35,744.0
JPMorgan Chase & Co	[2023-03-31]	DFND	42.0	27,539.0
Bank of America Corp /DE/	[2023-03-31]	DFND	3,605.0	24,612.0
Deutsche Bank AG	[2023-03-31]	DFND	5,564.0	20,943.0
Barclays PLC	[2023-03-31]	SOLE	19,840.0	19,840.0
First Republic Investment Management Inc	[2023-03-31]	SOLE	18,300.0	18,300.0
Morgan Stanley	[2023-03-31]	DFND	17,197.0	18,006.0
American International Group Inc	[2023-03-31]	SOLE	17,324.0	17,324.0
SG Americas Securities LLC	[2023-03-31]	SOLE	14,740.0	14,740.0
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