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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	7,935,525	7,936,880
OrbiMed Advisors LLC	[2025-06-30]	SOLE	5,693,589	5,693,589
Altshuler Shaham Ltd	[2025-06-30]	DFND	3,394,441	3,394,441
Decheng Capital LLC	[2025-06-30]	SOLE	3,285,293	3,285,293
TCG Crossover Management LLC	[2025-06-30]	SOLE	2,801,763	2,801,763
Enavate Sciences GP, LLC	[2025-06-30]	SOLE	2,459,703	2,459,703
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	2,439,538	2,439,538
VR Adviser LLC	[2025-06-30]	SOLE	2,295,319	2,295,319
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,149,375
BlackRock, Inc.	[2025-06-30]	SOLE	2,025,369	2,096,506
Omega Fund Management LLC	[2025-06-30]	SOLE	2,036,293	2,036,293
Samsara Biocapital LLC	[2025-06-30]	SOLE	1,443,231	1,443,231
Deep Track Capital LP	[2025-06-30]	SOLE	1,442,767	1,442,767
Wellington Management Group LLP	[2025-06-30]	DFND	0	1,225,295
Norges Bank	[2025-06-30]	SOLE	969,916	969,916
Siren, L.L.C.	[2025-06-30]	DFND	788,450	788,450
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	715,504	715,504
Geode Capital Management LLC	[2025-06-30]	DFND	646,635	646,635
Nantahala Capital Management LLC	[2025-06-30]	SOLE	594,971	594,971
Woodline Partners LP	[2025-06-30]	SOLE	558,252	558,252
State Street Corp	[2025-06-30]	DFND	432,275	481,375
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	365,790	365,790
Great Point Partners LLC	[2025-06-30]	SOLE	0	300,000
Marshall Wace LLP	[2025-06-30]	OTR	0	290,526
UBS Group AG	[2025-06-30]	DFND	232,887	232,887
Northern Trust Corp	[2025-06-30]	DFND	223,977	223,977
Lynx1 Capital Management LP	[2025-06-30]	OTR	0	219,247
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	178,253	178,253
Velan Capital Investment Management LP	[2025-06-30]	SOLE	107,000	107,000
Morgan Stanley	[2025-06-30]	DFND	99,167	99,308
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