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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Novo Holdings A/S	[2025-06-30]	SOLE	2,375,000	2,375,000
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	1,458,333	1,458,333
General American Investors Co Inc	[2025-06-30]	SOLE	354,361	354,361
Wells Fargo & Company/MN	[2025-06-30]	DFND	0	245,177
Citadel Advisors LLC	[2025-06-30]	DFND	35,738	35,738
Ironwood Investment Management LLC	[2025-06-30]	SOLE	25,135	25,135
Marex Group plc	[2025-06-30]	DFND	11,300	11,300
Morgan Stanley	[2025-06-30]	DFND	6,557	8,036
VSM Wealth Advisory LLC	[2025-06-30]	SOLE	4,000	4,000
Osaic Holdings Inc	[2025-06-30]	DFND	0	1,855
Gamma Investing LLC	[2025-06-30]	DFND	1,380	1,380
Ridgewood Investments LLC	[2025-06-30]	SOLE	0	550
Eversource Wealth Advisors LLC	[2025-06-30]	SOLE	93	93
RhumbLine Advisers	[2025-06-30]	SOLE	51	51
Raymond James Financial Inc	[2025-06-30]	DFND	0	41
Allworth Financial LP	[2025-06-30]	SOLE	0	7
UBS Group AG	[2025-06-30]	DFND	1	1
Activest Wealth Management	[2025-06-30]	SOLE	0	1
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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