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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Janus Henderson Group PLC	[2025-06-30]	DFND	0	6,134,405
Perceptive Advisors LLC	[2025-06-30]	SOLE	5,507,591	5,507,591
Darwin Global Management, Ltd.	[2025-06-30]	SOLE	4,129,618	4,129,618
Summit Partners Public Asset Management LLC	[2025-06-30]	SOLE	3,185,407	3,544,286
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	3,383,950	3,383,950
RTW Investments LP	[2025-06-30]	SOLE	3,051,878	3,051,878
Eventide Asset Management LLC	[2025-06-30]	SOLE	2,715,324	2,715,324
Goldman Sachs Group Inc	[2025-06-30]	DFND	2,617,297	2,617,297
NEA Management Company LLC	[2025-06-30]	DFND	2,263,138	2,263,138
Farallon Capital Management LLC	[2025-06-30]	OTR	1,810,000	1,810,000
Citadel Advisors LLC	[2025-06-30]	DFND	1,727,944	1,727,944
Wellington Management Group LLP	[2025-06-30]	DFND	0	1,629,848
Hood River Capital Management LLC	[2025-06-30]	SOLE	1,514,255	1,562,467
Caligan Partners LP	[2025-06-30]	SOLE	1,436,878	1,436,878
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	1,434,919	1,434,919
Vivo Capital LLC	[2025-06-30]	SOLE	1,393,432	1,393,432
Susquehanna International Group LLP	[2025-06-30]	OTR	0	1,390,200
UBS Group AG	[2025-06-30]	DFND	1,183,900	1,186,181
Franklin Resources Inc	[2025-06-30]	DFND	1,149,115	1,159,662
Federated Hermes Inc	[2025-06-30]	DFND	1,146,095	1,146,095
Holocene Advisors LP	[2025-06-30]	SOLE	1,075,662	1,075,662
Artia Global Partners LP	[2025-06-30]	SOLE	1,016,004	1,016,004
Duquesne Family Office LLC	[2025-06-30]	DFND	1,002,080	1,002,080
Polar Capital Holdings Plc	[2025-06-30]	DFND	875,000	875,000
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	816,715	816,715
Jennison Associates LLC	[2025-06-30]	DFND	744,121	744,121
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	620,798	674,056
Jane Street Group LLC	[2025-06-30]	DFND	404,930	640,330
Loomis Sayles & Co L P	[2025-06-30]	DFND	620,594	631,709
Lord Abbett & Co LLC	[2025-06-30]	SOLE	602,254	626,052
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