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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2023-03-31]	SOLE	0.0	6,317,990.0
NEA Management Company LLC	[2023-03-31]	DFND	5,584,753.0	5,584,753.0
FMR LLC	[2023-03-31]	DFND	4,567,179.0	4,567,179.0
OrbiMed Advisors LLC	[2023-03-31]	SOLE	4,260,691.0	4,260,691.0
Vivo Capital LLC	[2023-03-31]	SOLE	4,249,918.0	4,249,918.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	3,291,473.0
Deep Track Capital LP	[2023-03-31]	SOLE	3,187,415.0	3,187,415.0
Fairmount Funds Management LLC	[2023-03-31]	SOLE	3,127,429.0	3,127,429.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	2,944,349.0	2,944,349.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	2,733,790.0	2,733,790.0
Octagon Capital Advisors LP	[2023-03-31]	SOLE	2,468,000.0	2,468,000.0
Carlyle Group Inc.	[2023-03-31]	DFND	0.0	2,457,500.0
Woodline Partners LP	[2023-03-31]	SOLE	1,744,264.0	1,744,264.0
Aisling Capital Management LP	[2023-03-31]	SOLE	1,115,352.0	1,115,352.0
Jennison Associates LLC	[2023-03-31]	DFND	1,028,998.0	1,028,998.0
Paradigm Biocapital Advisors LP	[2023-03-31]	SOLE	962,361.0	962,361.0
Nicholas Investment Partners LP	[2023-03-31]	SOLE	941,300.0	941,300.0
Avidity Partners Management LP	[2023-03-31]	SOLE	878,800.0	878,800.0
Samsara Biocapital LLC	[2023-03-31]	SOLE	695,001.0	695,001.0
Millennium Management LLC	[2023-03-31]	SOLE	550,762.0	550,762.0
Parkman Healthcare Partners LLC	[2023-03-31]	SOLE	487,995.0	487,995.0
Ally Bridge Group NY LLC	[2023-03-31]	SOLE	487,631.0	487,631.0
Affinity Asset Advisors LLC	[2023-03-31]	SOLE	452,821.0	452,821.0
Two Sigma Investments LP	[2023-03-31]	SOLE	404,981.0	404,981.0
Federated Hermes Inc	[2023-03-31]	DFND	402,050.0	402,050.0
Moody Aldrich Partners LLC	[2023-03-31]	SOLE	156,210.0	351,670.0
BlackRock Inc.	[2023-03-31]	SOLE	347,226.0	347,226.0
Schonfeld Strategic Advisors LLC	[2023-03-31]	SOLE	335,700.0	335,700.0
Citadel Advisors LLC	[2023-03-31]	DFND	299,448.0	299,448.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	241,100.0	262,800.0
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