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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock, Inc.	[2025-06-30]	SOLE	5,405,205	5,731,799
Armistice Capital LLC	[2025-06-30]	SOLE	4,800,000	4,800,000
EcoR1 Capital LLC	[2025-06-30]	SOLE	3,917,546	3,917,546
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,179,827
Vestal Point Capital LP	[2025-06-30]	SOLE	1,475,000	1,475,000
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,308,938	1,362,369
Geode Capital Management LLC	[2025-06-30]	DFND	1,116,847	1,116,847
Erste Asset Management GmbH	[2025-06-30]	SOLE	1,116,793	1,116,793
Millennium Management LLC	[2025-06-30]	SOLE	903,161	903,161
State Street Corp	[2025-06-30]	DFND	839,720	893,920
Farallon Capital Management LLC	[2025-06-30]	OTR	715,000	715,000
Bank of America Corp /DE/	[2025-06-30]	DFND	8,686	576,482
Morgan Stanley	[2025-06-30]	DFND	490,630	563,439
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	551,523	551,523
UBS Group AG	[2025-06-30]	DFND	455,542	455,542
Northern Trust Corp	[2025-06-30]	DFND	397,185	397,185
Renaissance Technologies LLC	[2025-06-30]	SOLE	392,100	392,100
Royal Bank of Canada	[2025-06-30]	DFND	286,550	286,550
Goldman Sachs Group Inc	[2025-06-30]	DFND	280,916	280,916
AQR Capital Management LLC	[2025-06-30]	DFND	280,159	280,159
Fiduciary Trust Co	[2025-06-30]	SOLE	259,397	259,397
GSA Capital Partners LLP	[2025-06-30]	SOLE	224,629	224,629
JPMorgan Chase & Co	[2025-06-30]	DFND	198,280	220,291
Citadel Advisors LLC	[2025-06-30]	DFND	215,553	215,553
Bank of New York Mellon Corp	[2025-06-30]	DFND	175,624	188,656
Barclays PLC	[2025-06-30]	SOLE	171,831	171,831
Acadian Asset Management LLC	[2025-06-30]	DFND	156,715	156,715
HSBC Holdings PLC	[2025-06-30]	DFND	148,377	148,377
American Century Companies Inc	[2025-06-30]	DFND	138,269	138,269
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	123,050	123,050
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