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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Artal Group S.A.	[2023-03-31]	DFND	14,818,300.0	14,818,300.0
Contrarius Investment Management Ltd	[2023-03-31]	DFND	6,633,237.0	6,633,237.0
Balyasny Asset Management LP	[2023-03-31]	SOLE	4,673,511.0	4,673,511.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	4,327,923.0
BlackRock Inc.	[2023-03-31]	SOLE	3,556,966.0	3,632,298.0
Millennium Management LLC	[2023-03-31]	SOLE	3,376,605.0	3,526,605.0
Arrowstreet Capital Limited Partnership	[2023-03-31]	DFND	1,698,061.0	2,337,558.0
Susquehanna International Group LLP	[2023-03-31]	DFND	536,929.0	1,682,229.0
Two Sigma Investments LP	[2023-03-31]	SOLE	1,508,654.0	1,508,654.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	1,362,988.0	1,362,988.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	1,275,900.0	1,320,500.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,151,622.0	1,151,622.0
State Street Corp	[2023-03-31]	DFND	1,035,961.0	1,122,105.0
Caption Management LLC	[2023-03-31]	SOLE	898,231.0	898,231.0
Northern Trust Corp	[2023-03-31]	DFND	17,366.0	804,394.0
Federated Hermes Inc	[2023-03-31]	DFND	759,649.0	759,649.0
Morgan Stanley	[2023-03-31]	DFND	411,261.0	752,052.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	685,691.0
Citadel Advisors LLC	[2023-03-31]	DFND	672,648.0	672,648.0
Littlejohn & Co LLC	[2023-03-31]	SOLE	656,195.0	656,195.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	593,900.0	593,900.0
HRT Financial LP	[2023-03-31]	DFND	582,129.0	582,129.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	562,386.0	562,386.0
Jane Street Group LLC	[2023-03-31]	DFND	491,304.0	491,304.0
Walleye Trading LLC	[2023-03-31]	SOLE	474,137.0	474,137.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	470,168.0
Ergoteles LLC	[2023-03-31]	SOLE	408,164.0	408,164.0
Wolverine Trading LLC	[2023-03-31]	DFND	0.0	394,000.0
Cubist Systematic Strategies, LLC	[2023-03-31]	DFND	0.0	390,537.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	336,682.0	371,271.0
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