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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	8,884,348	8,884,363
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	5,400,000	5,400,000
BlackRock, Inc.	[2025-06-30]	SOLE	5,176,117	5,365,327
Driehaus Capital Management LLC	[2025-06-30]	SOLE	3,598,768	4,335,648
Braidwell LP	[2025-06-30]	SOLE	3,605,029	3,605,029
Janus Henderson Group PLC	[2025-06-30]	DFND	0	3,577,735
Capital International Investors	[2025-06-30]	DFND	3,181,549	3,181,549
Commodore Capital LP	[2025-06-30]	SOLE	3,025,000	3,025,000
Polar Capital Holdings Plc	[2025-06-30]	DFND	2,703,256	2,703,256
Wellington Management Group LLP	[2025-06-30]	DFND	0	2,174,761
Vestal Point Capital LP	[2025-06-30]	SOLE	2,000,000	2,000,000
Holocene Advisors LP	[2025-06-30]	SOLE	1,809,475	1,809,475
AllianceBernstein LP	[2025-06-30]	DFND	1,431,662	1,518,527
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,261,557	1,474,449
State Street Corp	[2025-06-30]	DFND	1,156,488	1,380,460
Deep Track Capital LP	[2025-06-30]	SOLE	1,350,000	1,350,000
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,290,100	1,290,100
JPMorgan Chase & Co	[2025-06-30]	DFND	1,119,130	1,256,308
Westfield Capital Management Co LP	[2025-06-30]	SOLE	815,620	1,152,605
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	1,100,000	1,100,000
Marshall Wace LLP	[2025-06-30]	OTR	0	1,020,254
Geode Capital Management LLC	[2025-06-30]	DFND	970,343	970,343
OrbiMed Advisors LLC	[2025-06-30]	DFND	276,890	947,877
Rock Springs Capital Management LP	[2025-06-30]	SOLE	931,681	931,681
Millennium Management LLC	[2025-06-30]	SOLE	882,835	882,835
Siren, L.L.C.	[2025-06-30]	DFND	812,761	812,761
Vanguard Group Inc	[2025-06-30]	SOLE	0	727,052
Jennison Associates LLC	[2025-06-30]	DFND	696,383	696,383
American Century Companies Inc	[2025-06-30]	DFND	569,114	679,857
Franklin Resources Inc	[2025-06-30]	DFND	666,466	666,466
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