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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	4,236,346	4,236,346
Acorn Capital Advisors LLC	[2025-06-30]	SOLE	3,418,995	3,418,995
BlackRock, Inc.	[2025-06-30]	SOLE	2,707,643	2,748,077
Caligan Partners LP	[2025-06-30]	SOLE	2,342,609	2,342,609
Sofinnova Investments Inc	[2025-06-30]	SOLE	2,194,278	2,194,278
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,896,342
Polar Capital Holdings Plc	[2025-06-30]	DFND	1,789,800	1,789,800
Geode Capital Management LLC	[2025-06-30]	DFND	848,461	848,461
State Street Corp	[2025-06-30]	DFND	740,122	780,145
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	693,693
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	516,857	516,857
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	336,249	382,721
Nantahala Capital Management LLC	[2025-06-30]	SOLE	351,878	351,878
Soleus Capital Management LP	[2025-06-30]	SOLE	349,982	349,982
Northern Trust Corp	[2025-06-30]	DFND	301,885	302,320
Morgan Stanley	[2025-06-30]	DFND	285,962	292,567
Stonepine Capital Management LLC	[2025-06-30]	SOLE	285,300	285,300
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	278,179	278,179
Bank of America Corp /DE/	[2025-06-30]	DFND	5,721	274,164
AQR Capital Management LLC	[2025-06-30]	DFND	246,293	246,298
Citadel Advisors LLC	[2025-06-30]	DFND	231,642	231,642
UBS Group AG	[2025-06-30]	DFND	229,072	229,072
Goldman Sachs Group Inc	[2025-06-30]	DFND	212,751	212,751
GSA Capital Partners LLP	[2025-06-30]	SOLE	186,062	186,062
Renaissance Technologies LLC	[2025-06-30]	SOLE	164,100	164,100
JPMorgan Chase & Co	[2025-06-30]	DFND	146,615	164,055
Infinitum Asset Management LLC	[2025-06-30]	SOLE	155,529	155,529
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	142,641	142,641
Millennium Management LLC	[2025-06-30]	SOLE	139,955	139,955
Two Sigma Investments LP	[2025-06-30]	SOLE	125,298	125,298
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