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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
EcoR1 Capital LLC	[2025-06-30]	SOLE	22,970,388	22,970,388
Rubric Capital Management LP	[2025-06-30]	SOLE	4,710,551	4,710,551
BVF Inc/IL	[2025-06-30]	DFND	0	4,308,935
Morgan Stanley	[2025-06-30]	DFND	4,165,692	4,177,614
Redmile Group LLC	[2025-06-30]	SOLE	4,150,627	4,150,627
BlackRock, Inc.	[2025-06-30]	SOLE	3,704,267	3,794,272
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,378,492
Blackstone Inc.	[2025-06-30]	OTR	0	1,656,790
Deutsche Bank AG	[2025-06-30]	DFND	92,694	1,544,763
ProSight Management LP	[2025-06-30]	SOLE	1,309,904	1,309,904
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,275,274	1,275,274
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	OTR	0	1,238,074
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	SOLE	918,382	1,182,363
Vestal Point Capital LP	[2025-06-30]	SOLE	1,150,000	1,150,000
Nextech Invest Ltd	[2025-06-30]	SOLE	1,113,946	1,113,946
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,059,367	1,111,982
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,100,000
State Street Corp	[2025-06-30]	DFND	997,509	1,088,459
Geode Capital Management LLC	[2025-06-30]	DFND	705,364	705,364
Nuveen, LLC	[2025-06-30]	DFND	653,160	654,916
Renaissance Technologies LLC	[2025-06-30]	SOLE	533,300	533,300
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	492,780	492,780
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	476,000	476,000
JPMorgan Chase & Co	[2025-06-30]	DFND	370,348	441,690
Goldman Sachs Group Inc	[2025-06-30]	DFND	428,792	428,857
Susquehanna International Group LLP	[2025-06-30]	OTR	259,137	381,037
Granahan Investment Management LLC	[2025-06-30]	SOLE	341,888	380,783
Jupiter Asset Management Ltd	[2025-06-30]	SOLE	369,499	369,499
Northern Trust Corp	[2025-06-30]	DFND	341,763	342,217
Citadel Advisors LLC	[2025-06-30]	DFND	310,455	310,455
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