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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	19,132,034	19,133,853
ARK Investment Management LLC	[2025-06-30]	SOLE	10,045,928	10,045,928
BlackRock, Inc.	[2025-06-30]	SOLE	8,222,561	8,360,550
Redmile Group LLC	[2025-06-30]	SOLE	8,253,316	8,253,316
Vanguard Group Inc	[2025-06-30]	SOLE	0	6,325,328
Fred Alger Management LLC	[2025-06-30]	SOLE	3,929,311	3,929,311
Woodline Partners LP	[2025-06-30]	SOLE	2,966,106	2,966,106
Ameriprise Financial Inc	[2025-06-30]	DFND	0	2,565,560
Geode Capital Management LLC	[2025-06-30]	DFND	2,445,450	2,445,450
Massachusetts Financial Services Co /MA/	[2025-06-30]	SOLE	2,227,123	2,227,123
UBS Group AG	[2025-06-30]	DFND	1,902,589	1,908,839
Bank of America Corp /DE/	[2025-06-30]	DFND	4,683	1,867,669
State Street Corp	[2025-06-30]	DFND	1,668,594	1,803,075
Royce & Associates LP	[2025-06-30]	SOLE	1,518,799	1,518,799
Sumitomo Mitsui Trust Group, Inc.	[2025-06-30]	DFND	1,461,729	1,461,729
Nikko Asset Management Americas Inc	[2025-06-30]	SOLE	0	1,447,484
Morgan Stanley	[2025-06-30]	DFND	384,371	1,249,278
Casdin Capital LLC	[2025-06-30]	SOLE	973,260	973,260
Susquehanna International Group LLP	[2025-06-30]	OTR	238,452	864,952
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	822,675	822,675
Northern Trust Corp	[2025-06-30]	DFND	799,752	799,752
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	701,793	784,153
Goldman Sachs Group Inc	[2025-06-30]	DFND	665,676	666,066
Marshall Wace LLP	[2025-06-30]	OTR	0	612,878
Two Sigma Investments LP	[2025-06-30]	SOLE	580,438	580,438
Two Sigma Advisers LP	[2025-06-30]	SOLE	494,000	521,000
Wellington Management Group LLP	[2025-06-30]	DFND	0	378,261
Lazard Asset Management LLC	[2025-06-30]	SOLE	366,906	366,906
Citadel Advisors LLC	[2025-06-30]	DFND	322,700	322,700
Nuveen, LLC	[2025-06-30]	DFND	315,743	315,743
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