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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	8,340,508	8,340,508
Sands Capital Alternatives, LLC	[2025-06-30]	SOLE	2,122,605	2,122,605
Citadel Advisors LLC	[2025-06-30]	DFND	1,895,519	1,895,519
Wellington Management Group LLP	[2025-06-30]	DFND	0	888,130
Vanguard Group Inc	[2025-06-30]	SOLE	0	588,794
Renaissance Technologies LLC	[2025-06-30]	SOLE	509,295	509,295
BlackRock, Inc.	[2025-06-30]	SOLE	406,201	407,622
Acorn Capital Advisors LLC	[2025-06-30]	SOLE	405,237	405,237
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	382,234	382,234
Jane Street Group LLC	[2025-06-30]	DFND	311,829	311,829
Millennium Management LLC	[2025-06-30]	SOLE	296,239	296,239
Marshall Wace LLP	[2025-06-30]	OTR	0	181,187
Two Sigma Investments LP	[2025-06-30]	SOLE	181,172	181,172
Geode Capital Management LLC	[2025-06-30]	DFND	164,362	164,362
Squarepoint Ops LLC	[2025-06-30]	DFND	0	152,605
HRT Financial LP	[2025-06-30]	DFND	145,895	145,895
Goldman Sachs Group Inc	[2025-06-30]	DFND	140,055	140,055
XTX Topco Ltd	[2025-06-30]	DFND	106,119	106,119
State Street Corp	[2025-06-30]	DFND	67,145	67,145
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	63,636	63,636
Morgan Stanley	[2025-06-30]	DFND	62,510	63,016
Northern Trust Corp	[2025-06-30]	DFND	46,776	46,776
Susquehanna International Group LLP	[2025-06-30]	OTR	43,860	43,860
Two Sigma Advisers LP	[2025-06-30]	SOLE	31,200	32,600
Citigroup Inc	[2025-06-30]	DFND	32,382	32,382
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	22,900	22,900
Baker Bros Advisors LP	[2025-06-30]	SOLE	22,809	22,809
Quadrature Capital Ltd	[2025-06-30]	OTR	0	22,175
AQR Capital Management LLC	[2025-06-30]	DFND	21,954	21,954
Barclays PLC	[2025-06-30]	SOLE	20,925	20,925
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