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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
venBio Partners LLC	[2025-06-30]	SOLE	9,699,925	9,699,925
Redmile Group LLC	[2025-06-30]	SOLE	3,391,455	3,391,455
Tang Capital Management LLC	[2025-06-30]	OTR	0	3,158,265
Almitas Capital LLC	[2025-06-30]	SOLE	2,538,355	2,538,355
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,590,840
Acadian Asset Management LLC	[2025-06-30]	DFND	1,267,999	1,267,999
Bank of America Corp /DE/	[2025-06-30]	DFND	0	1,035,127
BlackRock, Inc.	[2025-06-30]	SOLE	710,800	716,297
Two Sigma Advisers LP	[2025-06-30]	SOLE	671,700	703,300
Bank of Montreal /Can/	[2025-06-30]	DFND	668,747	668,747
Privium Fund Management B.V.	[2025-06-30]	SOLE	509,059	509,059
Millennium Management LLC	[2025-06-30]	SOLE	492,614	492,614
Two Sigma Investments LP	[2025-06-30]	SOLE	477,934	477,934
Geode Capital Management LLC	[2025-06-30]	DFND	315,421	315,421
Goldman Sachs Group Inc	[2025-06-30]	DFND	289,693	289,693
UBS Group AG	[2025-06-30]	DFND	288,685	288,685
Jane Street Group LLC	[2025-06-30]	DFND	203,266	203,266
Susquehanna International Group LLP	[2025-06-30]	OTR	163,813	163,813
Northern Trust Corp	[2025-06-30]	DFND	135,863	135,909
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	133,433	133,433
State Street Corp	[2025-06-30]	DFND	124,232	124,232
Morgan Stanley	[2025-06-30]	DFND	117,452	117,465
Marshall Wace LLP	[2025-06-30]	OTR	0	106,280
Bank of Nova Scotia	[2025-06-30]	SOLE	105,858	105,858
JPMorgan Chase & Co	[2025-06-30]	DFND	88,352	88,352
Renaissance Technologies LLC	[2025-06-30]	SOLE	85,399	85,399
GSA Capital Partners LLP	[2025-06-30]	SOLE	81,326	81,326
XTX Topco Ltd	[2025-06-30]	DFND	74,770	74,770
Citadel Advisors LLC	[2025-06-30]	DFND	65,500	65,500
Squarepoint Ops LLC	[2025-06-30]	DFND	0	58,307
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