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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Alpha Wave Global LP	[2025-06-30]	SOLE	3,707,757	3,707,757
Armistice Capital LLC	[2025-06-30]	SOLE	1,624,000	1,624,000
Point72 Asset Management LP	[2025-06-30]	DFND	0	1,329,755
Franklin Resources Inc	[2025-06-30]	DFND	1,162,608	1,162,608
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,076,319
Vestal Point Capital LP	[2025-06-30]	SOLE	950,000	950,000
Marshall Wace LLP	[2025-06-30]	OTR	0	937,407
72 Investment Holdings, LLC	[2025-06-30]	DFND	0	667,778
BlackRock, Inc.	[2025-06-30]	SOLE	557,180	561,848
Alkeon Capital Management LLC	[2025-06-30]	SOLE	477,101	477,101
Northern Trust Corp	[2025-06-30]	DFND	463,344	463,344
UBS Group AG	[2025-06-30]	DFND	428,216	428,216
Integral Health Asset Management LLC	[2025-06-30]	SOLE	400,000	400,000
Millennium Management LLC	[2025-06-30]	SOLE	302,862	302,862
AWM Investment Company Inc	[2025-06-30]	SOLE	280,483	280,483
Peapod Lane Capital LLC	[2025-06-30]	SOLE	222,053	278,857
OrbiMed Advisors LLC	[2025-06-30]	SOLE	0	250,000
Geode Capital Management LLC	[2025-06-30]	DFND	229,721	229,721
Almitas Capital LLC	[2025-06-30]	SOLE	195,145	195,145
Goldman Sachs Group Inc	[2025-06-30]	DFND	166,087	166,087
Stifel Financial Corp	[2025-06-30]	DFND	109,200	126,853
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	115,263	115,263
Ikarian Capital LLC	[2025-06-30]	SOLE	110,000	110,000
Jane Street Group LLC	[2025-06-30]	DFND	109,020	109,020
State Street Corp	[2025-06-30]	DFND	104,734	104,734
Laird Norton Wetherby Wealth Management LLC	[2025-06-30]	SOLE	84,162	84,162
Two Sigma Advisers LP	[2025-06-30]	SOLE	80,200	82,200
AQR Capital Management LLC	[2025-06-30]	DFND	74,561	74,561
Squarepoint Ops LLC	[2025-06-30]	DFND	0	67,948
SCS Capital Management LLC	[2025-06-30]	SOLE	66,777	66,777
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