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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
VR Adviser LLC	[2025-06-30]	SOLE	8,493,321	8,493,321
FMR LLC	[2025-06-30]	DFND	6,907,032	6,907,100
Wellington Management Group LLP	[2025-06-30]	DFND	0	3,805,710
RTW Investments LP	[2025-06-30]	SOLE	2,712,097	2,712,097
BlackRock, Inc.	[2025-06-30]	SOLE	2,508,699	2,562,539
Driehaus Capital Management LLC	[2025-06-30]	SOLE	1,974,935	2,310,755
Fairmount Funds Management LLC	[2025-06-30]	SOLE	2,048,647	2,048,647
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,046,425
Braidwell LP	[2025-06-30]	SOLE	1,478,512	1,478,512
AllianceBernstein LP	[2025-06-30]	DFND	1,304,627	1,388,149
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,290,464	1,290,464
State Street Corp	[2025-06-30]	DFND	1,186,437	1,259,258
Point72 Asset Management LP	[2025-06-30]	DFND	0	1,230,377
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,182,148	1,182,148
JPMorgan Chase & Co	[2025-06-30]	DFND	982,614	1,125,395
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	958,630	958,630
Woodline Partners LP	[2025-06-30]	SOLE	870,208	870,208
Franklin Resources Inc	[2025-06-30]	DFND	851,861	852,531
Mercer Global Advisors Inc /ADV	[2025-06-30]	SOLE	1	820,376
Geode Capital Management LLC	[2025-06-30]	DFND	782,641	782,641
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	694,399	694,399
Goldman Sachs Group Inc	[2025-06-30]	DFND	659,051	659,186
Jefferies Financial Group Inc.	[2025-06-30]	DFND	642,357	642,357
Siren, L.L.C.	[2025-06-30]	DFND	594,994	594,994
Bank of America Corp /DE/	[2025-06-30]	DFND	5,904	510,687
Janus Henderson Group PLC	[2025-06-30]	DFND	0	509,321
Citadel Advisors LLC	[2025-06-30]	DFND	507,259	507,259
Polar Capital Holdings Plc	[2025-06-30]	DFND	495,000	495,000
Morgan Stanley	[2025-06-30]	DFND	470,905	474,702
Novo Holdings A/S	[2025-06-30]	SOLE	449,392	449,392
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