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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RTW Investments LP	[2023-03-31]	SOLE	3,780,855.0	3,780,855.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,395,515.0
BlackRock Inc.	[2023-03-31]	SOLE	2,430,853.0	2,468,224.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	2,131,100.0
Fairmount Funds Management LLC	[2023-03-31]	SOLE	2,011,647.0	2,011,647.0
FMR LLC	[2023-03-31]	DFND	1,364,316.0	1,364,954.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	1,169,827.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	1,050,000.0	1,050,000.0
Millennium Management LLC	[2023-03-31]	SOLE	1,039,367.0	1,039,367.0
State Street Corp	[2023-03-31]	DFND	722,773.0	796,045.0
Alethea Capital Management LLC	[2023-03-31]	SOLE	785,683.0	785,683.0
Geode Capital Management LLC	[2023-03-31]	DFND	652,436.0	652,436.0
Susquehanna International Group LLP	[2023-03-31]	DFND	33,178.0	648,178.0
Avidity Partners Management LP	[2023-03-31]	SOLE	619,200.0	619,200.0
PFM Health Sciences LP	[2023-03-31]	DFND	0.0	606,081.0
Woodline Partners LP	[2023-03-31]	SOLE	570,825.0	570,825.0
Citadel Advisors LLC	[2023-03-31]	DFND	565,521.0	565,521.0
Holocene Advisors LP	[2023-03-31]	SOLE	529,144.0	529,144.0
Morgan Stanley	[2023-03-31]	DFND	175,086.0	447,772.0
Bellevue Group AG	[2023-03-31]	DFND	441,350.0	441,350.0
Boxer Capital, LLC	[2023-03-31]	OTR	400,000.0	400,000.0
Hood River Capital Management LLC	[2023-03-31]	SOLE	353,752.0	380,822.0
Nicholas Investment Partners LP	[2023-03-31]	SOLE	340,430.0	340,430.0
Tang Capital Management LLC	[2023-03-31]	OTR	0.0	320,000.0
Northern Trust Corp	[2023-03-31]	DFND	23,158.0	318,045.0
Ikarian Capital LLC	[2023-03-31]	SOLE	300,000.0	300,000.0
Cormorant Asset Management LP	[2023-03-31]	DFND	300,000.0	300,000.0
Iridian Asset Management LLC/CT	[2023-03-31]	SOLE	290,772.0	290,772.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	269,300.0	269,320.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	249,118.0	249,118.0
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