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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	7,235,590	7,243,912
Heights Capital Management Inc	[2025-06-30]	OTR	3,839,349	3,839,349
Cormorant Asset Management LP	[2025-06-30]	DFND	3,570,872	3,570,872
Aisling Capital Management LP	[2025-06-30]	SOLE	2,048,757	2,048,757
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,871,183
Woodline Partners LP	[2025-06-30]	SOLE	1,743,834	1,743,834
Blue Owl Capital Holdings LP	[2025-06-30]	DFND	0	1,300,000
BlackRock, Inc.	[2025-06-30]	SOLE	751,949	753,551
Federated Hermes Inc	[2025-06-30]	DFND	576,364	576,364
Diadema Partners LP	[2025-06-30]	SOLE	568,900	568,900
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	500,000	500,000
Millennium Management LLC	[2025-06-30]	SOLE	465,958	465,958
Citadel Advisors LLC	[2025-06-30]	DFND	433,800	433,800
Morgan Stanley	[2025-06-30]	DFND	383,060	386,524
Burkehill Global Management LP	[2025-06-30]	SOLE	350,000	350,000
Two Sigma Investments LP	[2025-06-30]	SOLE	349,647	349,647
AQR Capital Management LLC	[2025-06-30]	DFND	333,723	333,726
Susquehanna International Group LLP	[2025-06-30]	OTR	17,414	314,014
Two Sigma Advisers LP	[2025-06-30]	SOLE	277,200	296,800
Geode Capital Management LLC	[2025-06-30]	DFND	273,822	273,822
Scotia Capital Inc	[2025-06-30]	DFND	0	255,000
Superstring Capital Management LP	[2025-06-30]	SOLE	250,000	250,000
UBS Group AG	[2025-06-30]	DFND	247,663	247,663
Goldman Sachs Group Inc	[2025-06-30]	DFND	197,099	197,099
Sculptor Capital LP	[2025-06-30]	DFND	0	169,600
Janus Henderson Group PLC	[2025-06-30]	DFND	0	150,761
XTX Topco Ltd	[2025-06-30]	DFND	149,779	149,779
National Bank of Canada /FI/	[2025-06-30]	DFND	0	147,100
Northern Trust Corp	[2025-06-30]	DFND	136,926	136,926
Jane Street Group LLC	[2025-06-30]	DFND	109,592	125,792
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