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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	5,450,445	5,450,445
BVF Inc/IL	[2025-06-30]	DFND	0	3,466,000
Soleus Capital Management LP	[2025-06-30]	SOLE	3,011,818	3,011,818
NEA Management Company LLC	[2025-06-30]	DFND	2,294,261	2,294,261
BlackRock, Inc.	[2025-06-30]	SOLE	2,022,858	2,070,683
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,633,208	1,633,208
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,631,226
Eventide Asset Management LLC	[2025-06-30]	SOLE	1,389,427	1,389,427
Saturn V Capital Management LP	[2025-06-30]	SOLE	1,185,520	1,185,520
Braidwell LP	[2025-06-30]	SOLE	884,306	884,306
Morgan Stanley	[2025-06-30]	DFND	700,532	784,079
Ameriprise Financial Inc	[2025-06-30]	DFND	0	768,796
Citadel Advisors LLC	[2025-06-30]	DFND	754,154	754,154
Geode Capital Management LLC	[2025-06-30]	DFND	677,229	677,229
Vivo Capital LLC	[2025-06-30]	SOLE	610,500	610,500
State Street Corp	[2025-06-30]	DFND	542,466	587,404
Captrust Financial Advisors	[2025-06-30]	SOLE	475,355	570,441
Artisan Partners Limited Partnership	[2025-06-30]	SOLE	366,831	401,678
Pfizer Inc	[2025-06-30]	SOLE	349,406	349,406
Candriam S.C.A.	[2025-06-30]	SOLE	263,576	263,576
Bank of America Corp /DE/	[2025-06-30]	DFND	9,296	262,874
Northern Trust Corp	[2025-06-30]	DFND	256,867	257,039
Quantinno Capital Management LP	[2025-06-30]	SOLE	243,042	243,042
Balyasny Asset Management LP	[2025-06-30]	SOLE	239,504	239,504
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	233,059	233,059
Hennion & Walsh Asset Management Inc	[2025-06-30]	SOLE	174,493	174,493
Susquehanna International Group LLP	[2025-06-30]	OTR	59,625	121,325
Wellington Management Group LLP	[2025-06-30]	DFND	0	99,379
Millennium Management LLC	[2025-06-30]	SOLE	89,049	89,049
UBS Group AG	[2025-06-30]	DFND	54,592	84,592
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