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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
ARK Investment Management LLC	[2023-03-31]	SOLE	20,829,990.0	22,100,119.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	16,067,558.0	16,067,558.0
BlackRock Inc.	[2023-03-31]	SOLE	12,631,138.0	13,005,712.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	10,098,890.0
PRIMECAP Management Co/CA/	[2023-03-31]	SOLE	8,816,100.0	8,816,100.0
Sumitomo Mitsui Trust Holdings, Inc.	[2023-03-31]	DFND	8,017,330.0	8,017,330.0
Nikko Asset Management Americas Inc	[2023-03-31]	SOLE	6,823,163.0	8,017,330.0
Senvest Management LLC	[2023-03-31]	DFND	5,555,788.0	5,555,788.0
Wasatch Advisors LP	[2023-03-31]	SOLE	5,018,439.0	5,018,439.0
State Street Corp	[2023-03-31]	DFND	4,466,194.0	4,810,020.0
Hood River Capital Management LLC	[2023-03-31]	SOLE	3,568,517.0	3,866,849.0
Geode Capital Management LLC	[2023-03-31]	DFND	3,386,432.0	3,386,432.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	2,817,032.0	2,831,832.0
Polar Capital Holdings Plc	[2023-03-31]	DFND	2,338,142.0	2,338,142.0
Tamarack Advisers LP	[2023-03-31]	SOLE	2,250,000.0	2,250,000.0
BAMCO Inc /NY/	[2023-03-31]	DFND	0.0	2,212,952.0
Silvercrest Asset Management Group LLC	[2023-03-31]	SOLE	1,237,868.0	2,203,590.0
Northern Trust Corp	[2023-03-31]	DFND	145,349.0	1,821,256.0
Bank of America Corp /DE/	[2023-03-31]	DFND	25,374.0	1,790,930.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	1,571,099.0	1,571,099.0
Morgan Stanley	[2023-03-31]	DFND	1,272,320.0	1,528,050.0
Millennium Management LLC	[2023-03-31]	SOLE	1,512,865.0	1,512,865.0
Voya Investment Management LLC	[2023-03-31]	DFND	0.0	1,275,145.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	1,218,558.0	1,218,558.0
SilverArc Capital Management LLC	[2023-03-31]	SOLE	1,152,902.0	1,152,902.0
Raymond James & Associates	[2023-03-31]	SOLE	0.0	1,092,123.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	1,060,303.0
Uniplan Investment Counsel Inc	[2023-03-31]	SOLE	991,699.0	991,699.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	428,300.0	765,000.0
Algert Global LLC	[2023-03-31]	SOLE	664,934.0	664,934.0
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