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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock, Inc.	[2025-06-30]	SOLE	19,382,570	20,729,629
ARK Investment Management LLC	[2025-06-30]	SOLE	17,876,831	19,207,604
Baker Bros Advisors LP	[2025-06-30]	SOLE	12,883,844	12,883,844
Vanguard Group Inc	[2025-06-30]	SOLE	0	10,474,091
Wasatch Advisors LP	[2025-06-30]	SOLE	8,533,758	8,533,758
Sumitomo Mitsui Trust Group, Inc.	[2025-06-30]	DFND	6,069,837	6,069,837
Nikko Asset Management Americas Inc	[2025-06-30]	SOLE	5,278,895	6,062,129
Geode Capital Management LLC	[2025-06-30]	DFND	4,349,030	4,349,030
Senvest Management LLC	[2025-06-30]	DFND	4,005,568	4,005,568
State Street Corp	[2025-06-30]	DFND	3,559,398	3,828,870
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	3,722,759	3,752,104
Silvercrest Asset Management Group LLC	[2025-06-30]	SOLE	2,028,752	3,486,123
Millennium Management LLC	[2025-06-30]	SOLE	2,950,761	2,950,761
SilverArc Capital Management LLC	[2025-06-30]	SOLE	2,488,291	2,488,291
IEQ Capital LLC	[2025-06-30]	SOLE	2,142,739	2,142,739
AQR Capital Management LLC	[2025-06-30]	DFND	2,056,824	2,138,055
Goldman Sachs Group Inc	[2025-06-30]	DFND	2,065,933	2,066,328
Morgan Stanley	[2025-06-30]	DFND	1,703,892	2,047,010
Voya Investment Management LLC	[2025-06-30]	DFND	0	1,685,340
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	1,556,134	1,556,134
Northern Trust Corp	[2025-06-30]	DFND	1,544,306	1,545,156
PRIMECAP Management Co/CA/	[2025-06-30]	SOLE	1,315,400	1,315,400
Bank of America Corp /DE/	[2025-06-30]	DFND	24,701	1,286,280
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	1,225,154	1,225,154
Citadel Advisors LLC	[2025-06-30]	DFND	1,093,513	1,093,513
Two Sigma Investments LP	[2025-06-30]	SOLE	980,897	980,897
Renaissance Technologies LLC	[2025-06-30]	SOLE	765,500	765,500
Lazard Asset Management LLC	[2025-06-30]	SOLE	749,964	749,964
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	749,564	749,564
FMR LLC	[2025-06-30]	DFND	739,986	743,893
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