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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2023-03-31]	SOLE	0.0	13,381,054.0
Brown Capital Management LLC	[2023-03-31]	SOLE	5,765,411.0	8,601,423.0
BlackRock Inc.	[2023-03-31]	SOLE	8,187,997.0	8,287,247.0
HHLR Advisors Ltd	[2023-03-31]	OTR	0.0	7,703,514.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	7,636,561.0
State Street Corp	[2023-03-31]	DFND	1,897,579.0	2,059,272.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,869,470.0	1,869,470.0
Macquarie Group Ltd	[2023-03-31]	SOLE	1,723,423.0	1,723,423.0
New York State Common Retirement Fund	[2023-03-31]	SOLE	1,379,285.0	1,379,285.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	1,289,534.0	1,289,534.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	1,235,206.0
Blue Water Life Science Advisors LP	[2023-03-31]	SOLE	1,109,000.0	1,109,000.0
Northern Trust Corp	[2023-03-31]	DFND	55,294.0	967,689.0
Millennium Management LLC	[2023-03-31]	SOLE	952,175.0	952,175.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	934,461.0	934,461.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	668,674.0	668,674.0
FIL Ltd	[2023-03-31]	DFND	575,553.0	575,553.0
FMR LLC	[2023-03-31]	DFND	518,127.0	518,160.0
Morgan Stanley	[2023-03-31]	DFND	512,491.0	516,964.0
Lord Abbett & Co LLC	[2023-03-31]	SOLE	368,180.0	492,642.0
Miura Global Management LLC	[2023-03-31]	SOLE	435,900.0	435,900.0
Citadel Advisors LLC	[2023-03-31]	DFND	415,892.0	415,892.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	351,465.0	390,541.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	203,600.0	353,500.0
Susquehanna International Group LLP	[2023-03-31]	DFND	307,020.0	307,020.0
Ameriprise Financial Inc	[2023-03-31]	DFND	0.0	256,250.0
Vanguard Group Inc	[2023-03-31]	DFND	0.0	248,927.0
Voya Investment Management LLC	[2023-03-31]	DFND	0.0	205,743.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	205,124.0	205,134.0
Bank of America Corp /DE/	[2023-03-31]	DFND	18,023.0	182,859.0
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