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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock Inc.	[2023-03-31]	SOLE	14,512,933.0	14,625,382.0
FMR LLC	[2023-03-31]	DFND	12,863,209.0	12,864,812.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	9,955,980.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	7,526,617.0
State Street Corp	[2023-03-31]	DFND	4,551,504.0	4,753,900.0
American Century Companies Inc	[2023-03-31]	DFND	2,651,278.0	2,678,698.0
Polar Capital Holdings Plc	[2023-03-31]	DFND	2,611,692.0	2,611,692.0
RTW Investments LP	[2023-03-31]	SOLE	2,574,198.0	2,574,198.0
PFM Health Sciences LP	[2023-03-31]	DFND	0.0	2,399,545.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	2,270,391.0
Lord Abbett & Co LLC	[2023-03-31]	SOLE	2,195,621.0	2,239,421.0
Boxer Capital, LLC	[2023-03-31]	OTR	2,100,000.0	2,100,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,734,696.0	1,734,696.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	1,573,644.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	524,554.0	1,518,062.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	1,477,481.0
Artal Group S.A.	[2023-03-31]	DFND	1,367,023.0	1,367,023.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	1,202,010.0	1,253,919.0
Logos Global Management LP	[2023-03-31]	SOLE	1,250,000.0	1,250,000.0
Bank of America Corp /DE/	[2023-03-31]	DFND	40,063.0	1,203,255.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	239,344.0	1,127,037.0
Franklin Resources Inc	[2023-03-31]	DFND	1,082,468.0	1,084,644.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	1,031,017.0	1,074,524.0
Northern Trust Corp	[2023-03-31]	DFND	73,060.0	1,005,691.0
Balyasny Asset Management LP	[2023-03-31]	SOLE	952,004.0	952,004.0
Farallon Capital Management LLC	[2023-03-31]	OTR	938,072.0	938,072.0
Morgan Stanley	[2023-03-31]	DFND	650,422.0	812,244.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	745,307.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	722,681.0	722,681.0
Nicholas Investment Partners LP	[2023-03-31]	SOLE	610,990.0	610,990.0
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