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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Janus Henderson Group PLC	[2025-06-30]	DFND	0	1,145,660
Cormorant Asset Management LP	[2025-06-30]	DFND	1,059,331	1,059,331
SIO Capital Management LLC	[2025-06-30]	SOLE	512,338	512,338
Commodore Capital LP	[2025-06-30]	SOLE	500,000	500,000
Perceptive Advisors LLC	[2025-06-30]	SOLE	420,690	420,690
Vivo Capital LLC	[2025-06-30]	SOLE	251,572	251,572
BlackRock, Inc.	[2025-06-30]	SOLE	205,763	209,677
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	200,000	200,000
Morgan Stanley	[2025-06-30]	DFND	162,069	162,069
Point72 Asset Management LP	[2025-06-30]	DFND	0	135,020
Millennium Management LLC	[2025-06-30]	SOLE	111,371	111,371
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	69,004	69,004
Ikarian Capital LLC	[2025-06-30]	SOLE	65,431	65,431
Geode Capital Management LLC	[2025-06-30]	DFND	57,521	57,521
Walleye Capital LLC	[2025-06-30]	SOLE	53,430	53,430
Acuta Capital Partners LLC	[2025-06-30]	SOLE	48,474	48,474
Platinum Investment Management Ltd	[2025-06-30]	SOLE	28,308	28,308
Vanguard Group Inc	[2025-06-30]	SOLE	0	27,503
Northern Trust Corp	[2025-06-30]	DFND	24,922	24,922
State Street Corp	[2025-06-30]	DFND	24,150	24,655
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	19,164
Advisorshares Investments LLC	[2025-06-30]	SOLE	14,481	14,481
Readystate Asset Management LP	[2025-06-30]	SOLE	13,975	13,975
Nuveen, LLC	[2025-06-30]	DFND	12,487	12,487
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	11,604	11,604
Bank of New York Mellon Corp	[2025-06-30]	DFND	8,523	8,702
Barclays PLC	[2025-06-30]	SOLE	8,393	8,393
RhumbLine Advisers	[2025-06-30]	SOLE	1,966	6,612
Deutsche Bank AG	[2025-06-30]	DFND	114	5,486
Bank of America Corp /DE/	[2025-06-30]	DFND	782	4,734
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