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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Cormorant Asset Management LP	[2025-06-30]	DFND	8,325,000	8,325,000
Suvretta Capital Management LLC	[2025-06-30]	SOLE	6,804,091	6,804,091
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	6,800,000	6,800,000
BlackRock, Inc.	[2025-06-30]	SOLE	5,199,215	5,360,214
Federated Hermes Inc	[2025-06-30]	DFND	4,599,450	4,599,450
Franklin Resources Inc	[2025-06-30]	DFND	4,301,123	4,301,123
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,751,450
TCG Crossover Management LLC	[2025-06-30]	SOLE	3,572,335	3,572,335
Citadel Advisors LLC	[2025-06-30]	DFND	2,500,010	2,500,010
Geode Capital Management LLC	[2025-06-30]	DFND	1,592,048	1,592,048
State Street Corp	[2025-06-30]	DFND	1,443,649	1,515,549
Patient Square Capital LP	[2025-06-30]	SOLE	1,352,837	1,352,837
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,280,372	1,280,692
Essex Woodlands Management Inc	[2025-06-30]	SOLE	1,169,857	1,169,857
5AM Venture Management LLC	[2025-06-30]	SOLE	1,050,000	1,050,000
Aberdeen Group plc	[2025-06-30]	DFND	1,031,201	1,031,201
Susquehanna International Group LLP	[2025-06-30]	OTR	281,115	944,115
Bank of America Corp /DE/	[2025-06-30]	DFND	14,926	814,153
Morgan Stanley	[2025-06-30]	DFND	772,751	782,642
HSBC Holdings PLC	[2025-06-30]	SOLE	601,319	601,319
Nantahala Capital Management LLC	[2025-06-30]	SOLE	593,091	593,091
Blue Owl Capital Holdings LP	[2025-06-30]	DFND	0	562,594
Principia Wealth Advisory LLC	[2025-06-30]	SOLE	0	533,778
Deutsche Bank AG	[2025-06-30]	DFND	68,692	512,113
Northern Trust Corp	[2025-06-30]	DFND	505,456	505,778
Woodline Partners LP	[2025-06-30]	SOLE	500,335	500,335
FMR LLC	[2025-06-30]	DFND	443,067	446,305
Two Sigma Investments LP	[2025-06-30]	SOLE	376,776	376,776
Alyeska Investment Group LP	[2025-06-30]	SOLE	351,348	351,348
Granahan Investment Management LLC	[2025-06-30]	SOLE	305,164	340,984
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