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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Fred Alger Management LLC	[2025-06-30]	SOLE	1,608,040	1,618,649
Janus Henderson Group PLC	[2025-06-30]	DFND	0	1,394,852
OrbiMed Advisors LLC	[2025-06-30]	DFND	1,111,960	1,196,955
Federated Hermes Inc	[2025-06-30]	DFND	1,072,233	1,072,233
Tybourne Capital Management HK Ltd	[2025-06-30]	SOLE	786,647	786,647
BVF Inc/IL	[2025-06-30]	DFND	0	588,344
Cable Car Capital LP	[2025-06-30]	SOLE	500,000	500,000
Sphera Funds Management Ltd	[2025-06-30]	DFND	495,109	495,109
Vanguard Group Inc	[2025-06-30]	SOLE	0	486,001
Ikarian Capital LLC	[2025-06-30]	SOLE	476,443	476,443
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	333,333	333,333
Woodline Partners LP	[2025-06-30]	SOLE	331,987	331,987
Heights Capital Management Inc	[2025-06-30]	OTR	143,033	143,033
Millennium Management LLC	[2025-06-30]	SOLE	72,116	72,116
Perceptive Advisors LLC	[2025-06-30]	SOLE	68,192	68,192
Geode Capital Management LLC	[2025-06-30]	DFND	64,110	64,110
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	58,637
Mink Brook Asset Management LLC	[2025-06-30]	SOLE	38,893	38,893
BlackRock, Inc.	[2025-06-30]	SOLE	33,695	33,695
Envestnet Asset Management Inc	[2025-06-30]	SOLE	18,856	18,856
Alphaquest LLC	[2025-06-30]	SOLE	16,897	16,897
Royal Bank of Canada	[2025-06-30]	DFND	9,107	9,234
Garde Capital Inc	[2025-06-30]	SOLE	0	3,960
Vanguard Group Inc	[2025-06-30]	DFND	0	918
Private Trust Co NA	[2025-06-30]	DFND	192	192
Comerica Bank	[2025-06-30]	DFND	0	157
Morgan Stanley	[2025-06-30]	DFND	0	151
Group One Trading LLC	[2025-06-30]	SOLE	104	104
Bank of America Corp /DE/	[2025-06-30]	DFND	0	55
SBI Securities Co., Ltd.	[2025-06-30]	DFND	12	12
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