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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	8,054,847	8,299,828
Atlas Venture Life Science Advisors LLC	[2025-06-30]	SOLE	8,279,484	8,279,484
Siren, L.L.C.	[2025-06-30]	DFND	2,968,925	2,968,925
Renaissance Technologies LLC	[2025-06-30]	SOLE	2,580,780	2,580,780
FMR LLC	[2025-06-30]	DFND	2,332,717	2,345,624
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,275,499
Baker Bros Advisors LP	[2025-06-30]	SOLE	1,944,945	1,944,945
Acadian Asset Management LLC	[2025-06-30]	DFND	1,233,471	1,233,471
BlackRock, Inc.	[2025-06-30]	SOLE	1,148,264	1,161,578
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,064,090	1,064,090
Millennium Management LLC	[2025-06-30]	SOLE	1,061,606	1,061,606
Yiheng Capital Management LP	[2025-06-30]	SOLE	1,055,269	1,055,269
Morgan Stanley	[2025-06-30]	DFND	912,734	912,834
UBS Group AG	[2025-06-30]	DFND	884,902	884,902
Bank of America Corp /DE/	[2025-06-30]	DFND	0	871,951
Militia Capital Partners, LP	[2025-06-30]	SOLE	173,605	542,347
Squarepoint Ops LLC	[2025-06-30]	DFND	0	518,270
Geode Capital Management LLC	[2025-06-30]	DFND	498,080	498,080
TD Asset Management Inc	[2025-06-30]	SOLE	340,686	340,686
Citadel Advisors LLC	[2025-06-30]	DFND	307,760	307,760
Susquehanna International Group LLP	[2025-06-30]	OTR	249,277	249,277
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	236,856	236,856
State Street Corp	[2025-06-30]	DFND	206,116	206,116
Two Sigma Advisers LP	[2025-06-30]	SOLE	184,400	191,400
Price T Rowe Associates Inc /MD/	[2025-06-30]	DFND	162,783	162,783
Palo Alto Investors LP	[2025-06-30]	SOLE	150,475	150,475
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	148,186	148,186
Manufacturers Life Insurance Company the	[2025-06-30]	DFND	143,980	143,980
Northern Trust Corp	[2025-06-30]	DFND	133,090	133,090
Two Sigma Investments LP	[2025-06-30]	SOLE	105,961	105,961
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