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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2023-03-31]	SOLE	0.0	31,544,806.0
BlackRock Inc.	[2023-03-31]	SOLE	30,934,685.0	31,498,755.0
Deep Track Capital LP	[2023-03-31]	SOLE	26,867,479.0	26,867,479.0
State Street Corp	[2023-03-31]	DFND	24,643,872.0	25,557,601.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	21,590,687.0
NEA Management Company LLC	[2023-03-31]	DFND	21,347,838.0	21,347,838.0
Vivo Capital LLC	[2023-03-31]	SOLE	19,282,834.0	19,282,834.0
TCG Crossover Management LLC	[2023-03-31]	SOLE	17,765,213.0	17,765,213.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	10,974,066.0
Bioimpact Capital LLC	[2023-03-31]	SOLE	8,401,565.0	8,401,565.0
Sofinnova Investments Inc	[2023-03-31]	SOLE	8,274,892.0	8,274,892.0
FMR LLC	[2023-03-31]	DFND	8,133,974.0	8,142,625.0
Geode Capital Management LLC	[2023-03-31]	DFND	8,081,850.0	8,081,850.0
Citadel Advisors LLC	[2023-03-31]	DFND	7,107,203.0	7,107,203.0
Fairmount Funds Management LLC	[2023-03-31]	SOLE	7,104,358.0	7,104,358.0
Artal Group S.A.	[2023-03-31]	DFND	5,565,889.0	5,565,889.0
Millennium Management LLC	[2023-03-31]	SOLE	5,325,894.0	5,325,894.0
Northern Trust Corp	[2023-03-31]	DFND	348,801.0	4,239,955.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	4,014,130.0
Logos Global Management LP	[2023-03-31]	SOLE	3,550,000.0	3,550,000.0
Walleye Capital LLC	[2023-03-31]	SOLE	3,489,434.0	3,489,434.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	3,061,224.0	3,061,224.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	2,993,100.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	2,396,873.0	2,397,053.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	2,316,193.0
Octagon Capital Advisors LP	[2023-03-31]	SOLE	2,278,000.0	2,278,000.0
Susquehanna International Group LLP	[2023-03-31]	DFND	1,241,314.0	2,233,214.0
Avidity Partners Management LP	[2023-03-31]	SOLE	2,128,000.0	2,128,000.0
Rafferty Asset Management LLC	[2023-03-31]	SOLE	1,844,634.0	1,844,634.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	1,644,388.0	1,644,388.0
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