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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Wellington Management Group LLP	[2024-06-30]	DFND	0.0	7,547,920.0
FMR LLC	[2024-06-30]	DFND	5,744,809.0	5,744,809.0
Janus Henderson Group PLC	[2024-06-30]	DFND	0.0	3,354,269.0
Capital Research Global Investors	[2024-06-30]	DFND	3,131,310.0	3,131,310.0
Logos Global Management LP	[2024-06-30]	SOLE	3,100,000.0	3,100,000.0
Driehaus Capital Management LLC	[2024-06-30]	SOLE	2,232,008.0	2,577,136.0
BVF Inc/IL	[2024-06-30]	DFND	0.0	2,487,762.0
Federated Hermes Inc	[2024-06-30]	DFND	2,407,206.0	2,407,206.0
Price T Rowe Associates Inc /MD/	[2024-06-30]	SOLE	2,283,239.0	2,313,521.0
RA Capital Management LP	[2024-06-30]	SOLE	1,896,772.0	1,896,772.0
Citadel Advisors LLC	[2024-06-30]	DFND	1,569,785.0	1,569,785.0
Capital International Investors	[2024-06-30]	DFND	1,498,644.0	1,498,644.0
FIL Ltd	[2024-06-30]	DFND	1,214,877.0	1,307,968.0
Millennium Management LLC	[2024-06-30]	SOLE	1,139,292.0	1,260,392.0
Adage Capital Partners GP LLC	[2024-06-30]	SOLE	1,213,099.0	1,213,099.0
Octagon Capital Advisors LP	[2024-06-30]	SOLE	1,140,060.0	1,140,060.0
Avidity Partners Management LP	[2024-06-30]	SOLE	1,075,000.0	1,075,000.0
Rock Springs Capital Management LP	[2024-06-30]	SOLE	1,065,462.0	1,065,462.0
Deep Track Capital LP	[2024-06-30]	SOLE	950,000.0	950,000.0
BlackRock Finance, Inc.	[2024-06-30]	SOLE	916,679.0	943,019.0
Deerfield Management Company LP Series C	[2024-06-30]	DFND	844,407.0	844,407.0
Alyeska Investment Group LP	[2024-06-30]	SOLE	707,390.0	707,390.0
Casdin Capital LLC	[2024-06-30]	SOLE	1,116,867.0	700,000.0
T. Rowe Price Investment Management, Inc.	[2024-06-30]	SOLE	692,824.0	696,498.0
TCG Crossover Management LLC	[2024-06-30]	SOLE	694,547.0	694,547.0
Goldman Sachs Group Inc	[2024-06-30]	DFND	682,363.0	682,363.0
Franklin Resources Inc	[2024-06-30]	DFND	645,709.0	645,709.0
First Light Asset Management LLC	[2024-06-30]	SOLE	590,647.0	590,647.0
Vestal Point Capital LP	[2024-06-30]	SOLE	560,000.0	560,000.0
Bellevue Group AG	[2024-06-30]	DFND	557,321.0	557,321.0
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