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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	10,617,062	10,617,062
Takeda Pharmaceutical Co Ltd	[2025-06-30]	DFND	6,724,000	6,724,000
Tang Capital Management LLC	[2025-06-30]	OTR	0	4,920,000
EcoR1 Capital LLC	[2025-06-30]	SOLE	2,420,243	2,420,243
Lightspeed Management Company LLC	[2025-06-30]	SOLE	2,303,871	2,303,871
Franklin Resources Inc	[2025-06-30]	DFND	1,953,642	1,953,642
Deerfield Management Company LP	[2025-06-30]	DFND	1,882,654	1,882,654
Carlyle Group Inc.	[2025-06-30]	DFND	0	1,838,486
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,451,205
Balyasny Asset Management LP	[2025-06-30]	SOLE	976,297	976,297
StepStone Group LP	[2025-06-30]	DFND	826,569	826,569
Goldman Sachs Group Inc	[2025-06-30]	DFND	455,600	460,505
Samsara Biocapital LLC	[2025-06-30]	SOLE	399,637	399,637
Trium Capital LLP	[2025-06-30]	SOLE	395,188	395,188
BlackRock, Inc.	[2025-06-30]	SOLE	387,533	387,533
Qiming US Ventures Management LLC	[2025-06-30]	SOLE	372,615	372,615
Deutsche Bank AG	[2025-06-30]	DFND	15,565	314,468
Acadian Asset Management LLC	[2025-06-30]	DFND	308,595	308,595
Geode Capital Management LLC	[2025-06-30]	DFND	255,254	255,254
Stonepine Capital Management LLC	[2025-06-30]	SOLE	226,009	226,009
Two Sigma Advisers LP	[2025-06-30]	SOLE	204,800	211,600
RBF Capital, LLC	[2025-06-30]	SOLE	200,000	200,000
Millennium Management LLC	[2025-06-30]	SOLE	176,327	176,327
Morgan Stanley	[2025-06-30]	DFND	169,414	174,906
Two Sigma Investments LP	[2025-06-30]	SOLE	170,209	170,209
Rangeley Capital LLC	[2025-06-30]	SOLE	153,790	153,790
State Street Corp	[2025-06-30]	DFND	110,264	110,264
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	109,153	109,153
Zacks Investment Management	[2025-06-30]	SOLE	92,803	92,803
BML Capital Management LLC	[2025-06-30]	SOLE	0	91,913
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