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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2023-03-31]	SOLE	0.0	6,144,881.0
MPM Asset Management LLC	[2023-03-31]	SOLE	4,284,172.0	4,284,172.0
Bioimpact Capital LLC	[2023-03-31]	SOLE	2,388,011.0	2,388,011.0
PFM Health Sciences LP	[2023-03-31]	DFND	0.0	2,217,220.0
Rubric Capital Management LP	[2023-03-31]	SOLE	1,935,357.0	1,935,357.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	1,531,463.0
Millennium Management LLC	[2023-03-31]	SOLE	1,097,348.0	1,097,348.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	1,000,597.0	1,000,597.0
Sphera Funds Management Ltd	[2023-03-31]	DFND	626,810.0	626,810.0
DC Funds, LP	[2023-03-31]	SOLE	589,102.0	589,102.0
Laurion Capital Management LP	[2023-03-31]	SOLE	522,900.0	522,900.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	460,925.0
Alyeska Investment Group LP	[2023-03-31]	SOLE	397,808.0	397,808.0
Geode Capital Management LLC	[2023-03-31]	DFND	129,832.0	129,832.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	120,936.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	81,711.0	81,711.0
Acadian Asset Management LLC	[2023-03-31]	DFND	78,671.0	78,671.0
Schonfeld Strategic Advisors LLC	[2023-03-31]	SOLE	73,418.0	73,418.0
HBK Sorce Advisory LLC	[2023-03-31]	SOLE	0.0	52,908.0
State Street Corp	[2023-03-31]	DFND	50,768.0	50,768.0
Edgewood Management LLC	[2023-03-31]	SOLE	50,000.0	50,000.0
Man Group plc	[2023-03-31]	DFND	45,132.0	45,132.0
BlackRock Inc.	[2023-03-31]	SOLE	38,994.0	38,994.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	34,100.0	34,100.0
Two Sigma Investments LP	[2023-03-31]	SOLE	25,837.0	25,837.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	19,906.0
Prudential Financial Inc	[2023-03-31]	DFND	9,900.0	19,800.0
Bailard Inc	[2023-03-31]	SOLE	18,127.0	18,127.0
Dimensional Fund Advisors LP	[2023-03-31]	DFND	0.0	7,264.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	6,062.0	6,062.0
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