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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Opaleye Management Inc	[2023-03-31]	SOLE	3,775,000.0	3,775,000.0
Braidwell LP	[2023-03-31]	SOLE	1,452,538.0	1,452,538.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,375,969.0
Private Capital Management LLC	[2023-03-31]	DFND	537,385.0	1,165,721.0
Portolan Capital Management LLC	[2023-03-31]	SOLE	1,072,969.0	1,072,969.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	944,556.0	962,612.0
Morgan Stanley	[2023-03-31]	DFND	874,438.0	950,830.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	802,450.0	802,450.0
Invictus Private Wealth LLC	[2023-03-31]	SOLE	639,316.0	639,316.0
BlackRock Inc.	[2023-03-31]	SOLE	492,232.0	495,576.0
Ophir Asset Management Pty Ltd	[2023-03-31]	SOLE	438,134.0	438,134.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	397,360.0	423,067.0
Susquehanna International Group LLP	[2023-03-31]	DFND	333,221.0	393,821.0
EAM Investors LLC	[2023-03-31]	SOLE	180,825.0	387,193.0
Acadian Asset Management LLC	[2023-03-31]	DFND	369,662.0	369,662.0
Wasatch Advisors LP	[2023-03-31]	SOLE	321,090.0	350,664.0
Uniplan Investment Counsel Inc	[2023-03-31]	SOLE	327,434.0	327,434.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	272,200.0	309,700.0
Driehaus Capital Management LLC	[2023-03-31]	SOLE	246,244.0	296,054.0
Two Sigma Investments LP	[2023-03-31]	SOLE	275,147.0	275,147.0
Geode Capital Management LLC	[2023-03-31]	DFND	267,535.0	267,535.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	253,900.0
Millennium Management LLC	[2023-03-31]	SOLE	243,067.0	243,067.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	237,600.0	237,600.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	236,597.0
Franklin Resources Inc	[2023-03-31]	DFND	217,396.0	217,396.0
Jane Street Group LLC	[2023-03-31]	DFND	182,825.0	182,825.0
Birchview Capital LP	[2023-03-31]	SOLE	180,000.0	180,000.0
Westside Investment Management Inc	[2023-03-31]	SOLE	0.0	150,609.0
Deutsche Bank AG	[2023-03-31]	DFND	0.0	139,418.0
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