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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Opaleye Management Inc	[2025-06-30]	SOLE	3,905,000	3,905,000
BlackRock, Inc.	[2025-06-30]	SOLE	2,485,098	2,565,595
Private Capital Management LLC	[2025-06-30]	DFND	649,314	1,998,861
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,799,594
Citadel Advisors LLC	[2025-06-30]	DFND	935,342	935,342
Braidwell LP	[2025-06-30]	SOLE	872,246	872,246
Geode Capital Management LLC	[2025-06-30]	DFND	810,803	810,803
State Street Corp	[2025-06-30]	DFND	715,393	773,105
Marshall Wace LLP	[2025-06-30]	OTR	0	564,876
Royce & Associates LP	[2025-06-30]	SOLE	553,693	553,693
Susquehanna International Group LLP	[2025-06-30]	OTR	213,909	539,909
Rice Hall James & Associates LLC	[2025-06-30]	SOLE	347,574	370,627
Morgan Stanley	[2025-06-30]	DFND	333,405	365,015
Northern Trust Corp	[2025-06-30]	DFND	309,724	309,724
Jane Street Group LLC	[2025-06-30]	DFND	270,476	299,776
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	258,110	258,110
First TURN Management LLC	[2025-06-30]	SOLE	228,761	228,761
Stifel Financial Corp	[2025-06-30]	DFND	213,409	215,335
Bank of America Corp /DE/	[2025-06-30]	DFND	7,350	213,448
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	208,183	208,183
Westside Investment Management, Inc.	[2025-06-30]	SOLE	0	181,056
Diametric Capital LP	[2025-06-30]	DFND	155,465	155,465
Invesco Ltd.	[2025-06-30]	DFND	0	150,948
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	147,224	149,950
Renaissance Technologies LLC	[2025-06-30]	SOLE	142,517	142,517
Divisadero Street Capital Management LP	[2025-06-30]	SOLE	140,570	140,570
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	123,566	123,566
Woodmont Investment Counsel LLC	[2025-06-30]	SOLE	0	106,213
UBS Group AG	[2025-06-30]	DFND	67,888	104,396
Deutsche Bank AG	[2025-06-30]	DFND	617	101,895
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