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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	13,136,045	13,137,294
BlackRock, Inc.	[2025-06-30]	SOLE	8,334,634	8,841,401
Capital Research Global Investors	[2025-06-30]	DFND	6,552,691	6,552,691
Janus Henderson Group PLC	[2025-06-30]	DFND	0	6,206,238
Point72 Asset Management LP	[2025-06-30]	DFND	0	5,028,279
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,801,498
Federated Hermes Inc	[2025-06-30]	DFND	4,627,266	4,627,266
Deerfield Management Company LP	[2025-06-30]	DFND	3,915,311	3,915,311
State Street Corp	[2025-06-30]	DFND	3,154,129	3,385,794
Logos Global Management LP	[2025-06-30]	SOLE	3,345,000	3,345,000
Sofinnova Investments Inc	[2025-06-30]	SOLE	2,147,795	2,147,795
Baker Bros Advisors LP	[2025-06-30]	SOLE	2,118,728	2,118,728
Geode Capital Management LLC	[2025-06-30]	DFND	2,113,164	2,113,164
Citadel Advisors LLC	[2025-06-30]	DFND	1,875,603	1,875,603
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,627,614	1,805,136
Fiera Capital Corp	[2025-06-30]	OTR	985,953	1,490,586
Morgan Stanley	[2025-06-30]	DFND	1,420,567	1,453,377
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,238,094	1,238,094
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,227,886	1,228,184
Bank of America Corp /DE/	[2025-06-30]	DFND	16,442	923,705
Fisher Asset Management LLC	[2025-06-30]	DFND	480,267	922,092
Candriam S.C.A.	[2025-06-30]	SOLE	914,400	914,400
Eventide Asset Management LLC	[2025-06-30]	SOLE	771,844	771,844
UBS Group AG	[2025-06-30]	DFND	750,850	751,905
Ensign Peak Advisors, Inc	[2025-06-30]	SOLE	741,833	741,833
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	716,798	716,798
Northern Trust Corp	[2025-06-30]	DFND	702,082	702,108
DAFNA Capital Management LLC	[2025-06-30]	SOLE	619,090	619,090
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	525,878	525,878
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	511,132	511,132
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