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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Suvretta Capital Management LLC	[2025-06-30]	SOLE	12,030,129	12,030,129
Baker Bros Advisors LP	[2025-06-30]	SOLE	10,168,901	10,168,901
Perceptive Advisors LLC	[2025-06-30]	SOLE	9,383,456	9,383,456
RTW Investments LP	[2025-06-30]	SOLE	6,970,152	6,970,152
Vestal Point Capital LP	[2025-06-30]	SOLE	6,250,000	6,250,000
Wellington Management Group LLP	[2025-06-30]	DFND	0	5,318,624
Woodline Partners LP	[2025-06-30]	SOLE	3,877,631	3,877,631
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	3,144,157	3,144,157
Toronto Dominion Bank	[2025-06-30]	DFND	0	2,912,390
Morgan Stanley	[2025-06-30]	DFND	2,794,963	2,804,092
Sofinnova Investments Inc	[2025-06-30]	SOLE	2,240,528	2,240,528
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,034,825	1,034,825
Citadel Advisors LLC	[2025-06-30]	DFND	978,635	978,635
Wasatch Advisors LP	[2025-06-30]	SOLE	785,154	785,154
OrbiMed Advisors LLC	[2025-06-30]	SOLE	0	719,901
Aberdeen Group plc	[2025-06-30]	DFND	719,586	719,586
University of Texas/Texas AM Investment Management Co	[2025-06-30]	SOLE	697,431	697,431
Sphera Funds Management Ltd	[2025-06-30]	DFND	583,105	583,105
683 Capital Management LLC	[2025-06-30]	DFND	540,000	540,000
Schroder Investment Management Group	[2025-06-30]	SOLE	427,994	427,994
UBS Group AG	[2025-06-30]	DFND	401,269	404,269
Sectoral Asset Management Inc	[2025-06-30]	SOLE	0	332,270
TD Asset Management Inc	[2025-06-30]	SOLE	288,256	288,256
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	282,678	282,678
DAFNA Capital Management LLC	[2025-06-30]	SOLE	245,000	245,000
BlackRock, Inc.	[2025-06-30]	SOLE	241,451	241,451
Northern Trust Corp	[2025-06-30]	DFND	232,375	232,375
JPMorgan Chase & Co	[2025-06-30]	DFND	198,769	198,769
State Street Corp	[2025-06-30]	DFND	182,629	182,629
MYDA Advisors LLC	[2025-06-30]	SOLE	120,000	120,000
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