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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Viking Global Investors LP	[2023-03-31]	SOLE	6,639,199.0	6,639,199.0
RA Capital Management LP	[2023-03-31]	SOLE	0.0	3,853,867.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	3,615,383.0	3,615,383.0
BlackRock Inc.	[2023-03-31]	SOLE	2,305,983.0	2,332,925.0
State Street Corp	[2023-03-31]	DFND	2,007,050.0	2,075,990.0
Capital Research Global Investors	[2023-03-31]	DFND	1,751,913.0	1,751,913.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,693,380.0
FMR LLC	[2023-03-31]	DFND	1,608,941.0	1,609,027.0
Sofinnova Investments Inc	[2023-03-31]	SOLE	1,244,488.0	1,244,488.0
Bioimpact Capital LLC	[2023-03-31]	SOLE	1,192,281.0	1,192,281.0
Loomis Sayles & Co L P	[2023-03-31]	DFND	1,144,823.0	1,161,982.0
ArrowMark Colorado Holdings LLC	[2023-03-31]	SOLE	941,423.0	941,423.0
Millennium Management LLC	[2023-03-31]	SOLE	719,553.0	719,553.0
Geode Capital Management LLC	[2023-03-31]	DFND	609,817.0	609,817.0
Soleus Capital Management LP	[2023-03-31]	SOLE	438,002.0	438,002.0
Morgan Stanley	[2023-03-31]	DFND	347,896.0	376,220.0
Two Sigma Investments LP	[2023-03-31]	SOLE	335,803.0	335,803.0
Schroder Investment Management Group	[2023-03-31]	SOLE	321,389.0	321,389.0
Northern Trust Corp	[2023-03-31]	DFND	19,446.0	318,079.0
Woodline Partners LP	[2023-03-31]	SOLE	314,195.0	314,195.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	245,500.0	273,900.0
Russell Investments Group, Ltd.	[2023-03-31]	DFND	243,309.0	243,309.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	241,701.0	241,701.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	239,119.0
Platinum Investment Management Ltd	[2023-03-31]	SOLE	222,209.0	222,209.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	213,500.0	213,500.0
Candriam SCA	[2023-03-31]	SOLE	187,069.0	187,069.0
Bank of America Corp /DE/	[2023-03-31]	DFND	7,161.0	186,741.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	175,161.0	175,181.0
Rafferty Asset Management LLC	[2023-03-31]	SOLE	155,023.0	155,023.0
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