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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Yiheng Capital Management LP	[2023-03-31]	SOLE	2,644,926.0	2,644,926.0
NEA Management Company LLC	[2023-03-31]	DFND	1,462,586.0	1,462,586.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	686,040.0
Ikarian Capital LLC	[2023-03-31]	SOLE	292,599.0	292,599.0
Citigroup Inc	[2023-03-31]	DFND	23,000.0	23,000.0
Commonwealth Equity Services LLC	[2023-03-31]	SOLE	0.0	14,124.0
Morgan Stanley	[2023-03-31]	DFND	5,900.0	5,900.0
Newedge Advisors LLC	[2023-03-31]	SOLE	0.0	700.0
CWM LLC	[2023-03-31]	SOLE	0.0	100.0
Concourse Financial Group Securities Inc	[2023-03-31]	SOLE	0.0	0.0
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