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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Yiheng Capital Management LP	[2025-06-30]	SOLE	2,644,926	2,644,926
NEA Management Company LLC	[2025-06-30]	DFND	1,462,586	1,462,586
BVF Inc/IL	[2025-06-30]	DFND	0	686,040
Commonwealth Equity Services LLC	[2025-06-30]	SOLE	0	54,317
UBS Group AG	[2025-06-30]	DFND	18,508	27,448
Citadel Advisors LLC	[2025-06-30]	DFND	23,384	23,384
Wealth Enhancement Advisory Services LLC	[2025-06-30]	SOLE	0	16,558
Creative Planning	[2025-06-30]	SOLE	0	10,000
Morgan Stanley	[2025-06-30]	DFND	2,098	2,098
Atlantic Union Bankshares Corp	[2025-06-30]	SOLE	0	300
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	100
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
Covestor Ltd	[2025-06-30]	SOLE	0	0
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False

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