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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Velan Capital Investment Management LP	[2023-03-31]	SOLE	11,219,036.0	11,219,036.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	9,900,000.0
Carlyle Group Inc.	[2023-03-31]	DFND	0.0	8,761,891.0
Qiming US Ventures Management LLC	[2023-03-31]	SOLE	8,519,648.0	8,519,648.0
Soleus Capital Management LP	[2023-03-31]	SOLE	7,454,980.0	7,454,980.0
Octagon Capital Advisors LP	[2023-03-31]	SOLE	6,382,500.0	6,382,500.0
Franklin Resources Inc	[2023-03-31]	DFND	4,500,217.0	4,500,217.0
Sphera Funds Management Ltd	[2023-03-31]	DFND	4,044,008.0	4,044,008.0
Citadel Advisors LLC	[2023-03-31]	DFND	4,023,238.0	4,023,238.0
Driehaus Capital Management LLC	[2023-03-31]	SOLE	4,000,000.0	4,000,000.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,677,444.0
Kingdon Capital Management LLC	[2023-03-31]	DFND	3,040,000.0	3,040,000.0
Woodline Partners LP	[2023-03-31]	SOLE	3,000,000.0	3,000,000.0
Ally Bridge Group NY LLC	[2023-03-31]	SOLE	2,517,232.0	2,517,232.0
RTW Investments LP	[2023-03-31]	SOLE	2,329,809.0	2,329,809.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	1,781,583.0
Nantahala Capital Management LLC	[2023-03-31]	SOLE	1,688,454.0	1,688,454.0
BlackRock Inc.	[2023-03-31]	SOLE	1,256,517.0	1,256,517.0
Ikarian Capital LLC	[2023-03-31]	SOLE	1,126,287.0	1,126,287.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,070,314.0	1,070,314.0
SilverArc Capital Management LLC	[2023-03-31]	SOLE	500,000.0	500,000.0
Affinity Asset Advisors LLC	[2023-03-31]	SOLE	476,948.0	476,948.0
Fernwood Investment Management LLC	[2023-03-31]	SOLE	454,706.0	454,706.0
Morgan Stanley	[2023-03-31]	DFND	356,022.0	378,072.0
Boothbay Fund Management LLC	[2023-03-31]	OTR	0.0	233,407.0
Jane Street Group LLC	[2023-03-31]	DFND	211,010.0	211,010.0
State Street Corp	[2023-03-31]	DFND	199,094.0	199,094.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	155,286.0
Squarepoint Ops LLC	[2023-03-31]	DFND	0.0	139,887.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	110,200.0	110,200.0
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130028738