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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Soleus Capital Management LP	[2025-06-30]	SOLE	1,494,420	1,494,420
Velan Capital Investment Management LP	[2025-06-30]	SOLE	1,188,500	1,188,500
Carlyle Group Inc.	[2025-06-30]	DFND	0	1,066,189
Qiming US Ventures Management LLC	[2025-06-30]	SOLE	928,964	928,964
Morgan Stanley	[2025-06-30]	DFND	767,486	769,750
Kingdon Capital Management LLC	[2025-06-30]	DFND	684,707	684,707
Vanguard Group Inc	[2025-06-30]	SOLE	0	620,625
Integral Health Asset Management LLC	[2025-06-30]	SOLE	590,000	590,000
Rock Springs Capital Management LP	[2025-06-30]	SOLE	545,171	545,171
Franklin Resources Inc	[2025-06-30]	DFND	534,713	534,713
Citadel Advisors LLC	[2025-06-30]	DFND	427,944	427,944
UBS Group AG	[2025-06-30]	DFND	416,275	416,275
Bank of America Corp /DE/	[2025-06-30]	DFND	0	293,460
Goldman Sachs Group Inc	[2025-06-30]	DFND	249,793	249,793
Velan Capital Investment Management LP	[2025-06-30]	OTR	0	245,328
BlackRock, Inc.	[2025-06-30]	SOLE	225,205	225,605
Deutsche Bank AG	[2025-06-30]	DFND	160,000	160,000
Bank of Montreal /Can/	[2025-06-30]	DFND	151,920	158,133
Lion Point Capital LP	[2025-06-30]	SOLE	146,500	146,500
Millennium Management LLC	[2025-06-30]	SOLE	145,219	145,219
Jane Street Group LLC	[2025-06-30]	DFND	132,905	132,905
Geode Capital Management LLC	[2025-06-30]	DFND	131,130	131,130
Susquehanna International Group LLP	[2025-06-30]	OTR	60,886	124,886
JPMorgan Chase & Co	[2025-06-30]	DFND	65,088	65,088
Marshall Wace LLP	[2025-06-30]	OTR	0	50,686
State Street Corp	[2025-06-30]	DFND	44,754	44,754
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	29,773	38,892
Northern Trust Corp	[2025-06-30]	DFND	34,908	34,908
AQR Capital Management LLC	[2025-06-30]	DFND	34,837	34,837
XTX Topco Ltd	[2025-06-30]	DFND	27,348	27,348
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220152005