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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Catalys Pacific LLC	[2024-06-30]	SOLE	9,194,579.0	9,194,579.0
Samsara Biocapital LLC	[2024-06-30]	SOLE	5,074,916.0	5,074,916.0
RA Capital Management LP	[2024-06-30]	SOLE	4,850,984.0	4,850,984.0
TCG Crossover Management LLC	[2024-06-30]	SOLE	3,185,185.0	3,185,185.0
BlackRock Finance, Inc.	[2024-06-30]	SOLE	2,013,563.0	2,045,702.0
OrbiMed Advisors LLC	[2024-06-30]	DFND	460,400.0	2,021,424.0
SR One Capital Management LP	[2024-06-30]	SOLE	2,016,822.0	2,016,822.0
Adams Street Partners LLC	[2024-06-30]	SOLE	1,688,712.0	1,688,712.0
Franklin Resources Inc	[2024-06-30]	DFND	1,482,482.0	1,482,591.0
Laurion Capital Management LP	[2024-06-30]	SOLE	1,456,804.0	1,456,804.0
Vanguard Group Inc	[2024-06-30]	SOLE	0.0	1,194,412.0
Nantahala Capital Management LLC	[2024-06-30]	SOLE	1,065,012.0	1,065,012.0
Caligan Partners LP	[2024-06-30]	SOLE	745,758.0	745,758.0
American Century Companies Inc	[2024-06-30]	DFND	675,115.0	743,140.0
Jennison Associates LLC	[2024-06-30]	DFND	683,257.0	683,257.0
Octagon Capital Advisors LP	[2024-06-30]	SOLE	600,000.0	600,000.0
Geode Capital Management LLC	[2024-06-30]	DFND	582,326.0	582,326.0
Morgan Stanley	[2024-06-30]	DFND	433,481.0	471,524.0
State Street Corp	[2024-06-30]	DFND	442,339.0	465,139.0
Blue Owl Capital Holdings LP	[2024-06-30]	DFND	0.0	450,339.0
Sphera Funds Management Ltd	[2024-06-30]	DFND	442,752.0	442,752.0
Sectoral Asset Management Inc	[2024-06-30]	SOLE	436,058.0	438,748.0
Boothbay Fund Management LLC	[2024-06-30]	OTR	0.0	424,183.0
Rock Springs Capital Management LP	[2024-06-30]	SOLE	378,932.0	378,932.0
Affinity Asset Advisors LLC	[2024-06-30]	SOLE	327,959.0	327,959.0
ExodusPoint Capital Management LP	[2024-06-30]	SOLE	274,316.0	274,316.0
FMR LLC	[2024-06-30]	DFND	270,186.0	271,095.0
Driehaus Capital Management LLC	[2024-06-30]	SOLE	257,371.0	257,371.0
Charles Schwab Investment Management Inc	[2024-06-30]	SOLE	203,935.0	203,935.0
Northern Trust Corp	[2024-06-30]	DFND	2,571.0	167,801.0
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