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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Catalys Pacific LLC	[2025-06-30]	SOLE	8,903,838	8,903,838
RA Capital Management LP	[2025-06-30]	SOLE	6,147,280	6,147,280
Samsara Biocapital LLC	[2025-06-30]	SOLE	5,674,916	5,674,916
SR One Capital Management LP	[2025-06-30]	SOLE	3,127,933	3,127,933
BlackRock, Inc.	[2025-06-30]	SOLE	3,024,258	3,097,760
Capital International Investors	[2025-06-30]	DFND	2,899,020	2,899,020
Integral Health Asset Management LLC	[2025-06-30]	SOLE	2,700,000	2,700,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,242,382
Caligan Partners LP	[2025-06-30]	SOLE	2,017,352	2,017,352
Franklin Resources Inc	[2025-06-30]	DFND	1,803,010	1,803,597
Laurion Capital Management LP	[2025-06-30]	SOLE	1,762,582	1,762,582
Suvretta Capital Management LLC	[2025-06-30]	SOLE	1,744,492	1,744,492
State Street Corp	[2025-06-30]	DFND	1,394,810	1,443,559
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,139,768	1,267,993
Jennison Associates LLC	[2025-06-30]	DFND	1,235,322	1,235,322
Geode Capital Management LLC	[2025-06-30]	DFND	954,560	954,560
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	900,000	900,000
American Century Companies Inc	[2025-06-30]	DFND	716,566	834,781
Candriam S.C.A.	[2025-06-30]	SOLE	824,187	824,187
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	816,926
OrbiMed Advisors LLC	[2025-06-30]	DFND	260,271	760,351
Stempoint Capital LP	[2025-06-30]	SOLE	551,000	631,586
Goldman Sachs Group Inc	[2025-06-30]	DFND	626,737	626,787
Morgan Stanley	[2025-06-30]	DFND	550,754	587,830
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	574,207	574,207
22NW LP	[2025-06-30]	SOLE	560,042	560,042
Sphera Funds Management Ltd	[2025-06-30]	DFND	480,974	480,974
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	463,601	463,601
Deutsche Bank AG	[2025-06-30]	DFND	801	456,914
Pale Fire Capital SE	[2025-06-30]	DFND	0	446,626
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