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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Nextech Invest Ltd	[2025-06-30]	SOLE	12,067,246	12,067,246
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	8,663,673	8,663,673
Vanguard Group Inc	[2025-06-30]	SOLE	0	7,643,667
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	5,673,852	5,673,852
AQR Capital Management LLC	[2025-06-30]	DFND	4,898,749	5,032,685
Rock Springs Capital Management LP	[2025-06-30]	SOLE	3,814,684	3,814,684
BlackRock, Inc.	[2025-06-30]	SOLE	3,739,717	3,763,419
SilverArc Capital Management LLC	[2025-06-30]	SOLE	3,128,421	3,128,421
Acadian Asset Management LLC	[2025-06-30]	DFND	2,955,280	2,955,280
Renaissance Technologies LLC	[2025-06-30]	SOLE	2,850,194	2,850,194
Millennium Management LLC	[2025-06-30]	SOLE	2,090,235	2,090,235
683 Capital Management LLC	[2025-06-30]	DFND	1,990,000	1,990,000
Catalio Capital Management LP	[2025-06-30]	SOLE	1,567,413	1,567,413
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,433,760	1,433,760
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	1,332,945	1,332,945
5AM Venture Management LLC	[2025-06-30]	SOLE	1,305,000	1,305,000
Geode Capital Management LLC	[2025-06-30]	DFND	1,049,205	1,049,205
Luminus Management LLC	[2025-06-30]	SOLE	1,039,314	1,039,314
Two Sigma Advisers LP	[2025-06-30]	SOLE	890,600	937,000
Two Sigma Investments LP	[2025-06-30]	SOLE	823,269	823,269
UBS Group AG	[2025-06-30]	DFND	770,501	775,501
Lion Point Capital LP	[2025-06-30]	SOLE	644,000	644,000
IEQ Capital LLC	[2025-06-30]	OTR	32,987	638,452
Alamea Verwaltungs GmbH	[2025-06-30]	SOLE	604,213	604,213
Jane Street Group LLC	[2025-06-30]	DFND	511,182	511,182
GSA Capital Partners LLP	[2025-06-30]	SOLE	471,681	471,681
State Street Corp	[2025-06-30]	DFND	446,110	452,110
Susquehanna International Group LLP	[2025-06-30]	OTR	449,369	449,369
Morgan Stanley	[2025-06-30]	DFND	351,597	357,597
Cerity Partners LLC	[2025-06-30]	SOLE	23,529	320,805
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